Use of polyols to obtain stable polymorphous forms of rifaximin
View Patent ↗Polyols stabilize polymorphous form of rifaximin, in particular the β form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph β is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
1. A method of preparing rifaximin in polymorphous form β comprising:
i) contacting rifaximin in solid state with an aqueous solution of one or more polyols to obtain a mixture of rifaximin and polyols wherein the aqueous solution comprises one or more polyols at a concentration of 5% to 50% (w/w), and
ii) drying the mixture of rifaximin in solid state and polyols.
2. The method of claim 1 , wherein the one or more polyols are selected from the group of polyols comprising two to seven carbon atoms and two to seven hydroxy groups.
3. The method of claim 1 , wherein the one or more polyols are selected from the group consisting of monosaccharides, disaccharides, polysaccharides, xanthan gum, di-hydroxy acids and poly-hydroxy acids.
4. The method of claim 1 , wherein the one or more polyols are compounds of formula I:
H—[O—CH—(X)—CH 2 ] n —OH (I)
wherein X is hydrogen or lower alkyl, and n is between 1 and 20.
5. The method of claim 1 , wherein the one or more polyols are compounds having the general formula H—[O—CH 2 —CH 2 ] n —OH, wherein n is between 2 and 14.
6. The method of claim 1 , wherein the polyol is 1,2,3-propanetriol or 1,2-propanediol.
7. The method of claim 1 , wherein the polyol is 1,2,3-propanetriol.
8. The method of claim 1 , wherein the polyol is 1,2-propanediol.
9. The method of claim 1 , wherein the contacting of said rifaximin in solid state with an aqueous solution of one or more polyols is at a temperature of between 20° C. and 90° C.
10. The method of claim 1 , wherein the contacting is for a period of time of between 1 and 24 hours.
11. The method of claim 1 , wherein the drying is at a temperature of between 40° C. and 80° C.
12. The method of claim 1 , wherein the drying is at ambient pressure or under vacuum.
13. The method of claim 1 , wherein the drying is for a period of time of between 2 and 72 hours.
14. The method of claim 1 , wherein the contacting step comprises spraying the polyol aqueous solution at concentrations of from 5 to 50% (w/w) on the rifaximin β in solid state in a fluid bed apparatus having an inlet temperature of between 20° C. and 90° C., and wherein the drying step comprises drying the mixture under an air flow at a temperature of between 30° C. and 90° C.
15. The method of claim 3 , wherein the polysaccharide is selected from the group consisting of starch, cellulose or derivatives thereof, dextrin and maltodextrin.
16. The method of claim 3 , wherein the one or more polyols are selected from the group consisting of fructose, dextrose and sucrose.
17. The method of claim 1 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of:
5.3°, 7.7° and 10.4°; or
5.3°, 7.7° and 17.7°; or
5.3°, 7.7° and 18.2°; or
5.3°, 10.4° and 17.7°; or
5.3°, 10.4° and 18.2°; or
7.7°, 10.4° and 17.7°; or
7.7°, 10.4° and 18.2°; or
8.9°, 17.7° and 18.2°; or
5.3°, 7.7°, 12.3° and 17.7°; or
5.3°, 7.7°, 12.3° and 18.2°; or
7.7°, 12.3°, 17.7° and 18.2°; or
5.3°, 7.7°, 12.3°, 17.7° and 18.2°; or
5.3°, 6.7°, 7.7°, 8.9°, 10.4°, 17.7°, 18.2 and 20.7.
18. The method of claim 1 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of 5.3, 7.7 and 18.2.
19. The method of claim 1 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of 5.3, 6.7, 7.7, 8.9, 10.4, 12.3, 17.7, 18.2, 18.6 and 20.7.
20. A stabilized polymorphous rifaximin β in solid state obtained by the method of claim 1 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of:
5.3°, 7.7° and 10.4°; or
5.3°, 7.7° and 17.7°; or
5.3°, 7.7° and 18.2°; or
5.3°, 10.4° and 17.7°; or
5.3°, 10.4° and 18.2°; or
7.7°, 10.4° and 17.7°; or
7.7°, 10.4° and 18.2°; or
8.9°, 17.7° and 18.2°; or
5.3°, 7.7°, 12.3° and 17.7°; or
5.3°, 7.7°, 12.3° and 18.2°; or
7.7°, 12.3°, 17.7° and 18.2°; or
5.3°, 7.7°, 12.3°, 17.7° and 18.2°; or
5.3°, 6.7°, 7.7°, 8.9°, 10.4°, 17.7°, 18.2 and 20.7.
21. A stabilized polymorphous β form of rifaximin in solid state comprising one or more polyols wherein the polyol is selected from the group consisting of a compound having the general formula H—[O—CH 2 —CH 2 ] n —OH, wherein n is between 2 and 16.
22. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the one or more polyols are selected form the group consisting of 1,2,3-propanetriol, and 1,2-propanediol.
23. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the one or more polyols are selected from the group consisting of polyols comprising two to seven carbon atoms and two to seven hydroxy groups.
24. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the one or more polyols are selected from the group consisting of monosaccharides, disaccharides, polysaccharides, xanthan gum, di-hydroxy acids and poly-hydroxy acids.
25. The stabilized polymorphous β form of rifaximin of claim 24 , wherein the polyols are selected from the group consisting of fructose, dextrose, sucrose, starch, cellulose and derivatives thereof, maltodextrin and dextrin.
26. The stabilized polymorphous β form of rifaximin of claim 21 , wherein n is between 2 and 10.
27. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the polyol is 1,2,3-propanetriol.
28. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the polyol is 1,2-propanediol.
29. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of:
5.3°, 7.7° and 10.4°; or
5.3°, 7.7° and 17.7°; or
5.3°, 7.7° and 18.2°; or
5.3°, 10.4° and 17.7°; or
5.3°, 10.4° and 18.2°; or
7.7°, 10.4° and 17.7°; or
7.7°, 10.4° and 18.2°; or
8.9°, 17.7° and 18.2°; or
5.3°, 7.7°, 12.3° and 17.7°; or
5.3°, 7.7°, 12.3° and 18.2°; or
7.7°, 12.3°, 17.7° and 18.2°; or
5.3°, 7.7°, 12.3°, 17.7° and 18.2°; or
5.3°, 6.7°, 7.7°, 8.9°, 10.4°, 17.7°, 18.2 and 20.7.
30. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of 5.3, 7.7 and 18.2.
31. The stabilized polymorphous β form of rifaximin of claim 21 , wherein the polymorphous form β is characterized by peaks at the values of the diffraction angles 2θ of 5.3, 6.7, 7.7, 8.9, 10.4, 12.3, 17.7, 18.2, 18.6 and 20.7.
32. A pharmaceutical composition for the treatment of pathologies that need antibiotic therapy, said composition comprising the stabilized polymorphous β form of rifaximin of claim 24 and an excipient.
33. The pharmaceutical composition of claim 32 , wherein the rifaximin is in the form of gastroresistant microgranules.
34. The pharmaceutical composition of claim 33 , wherein the composition is in thermo-welded bags.
35. The pharmaceutical composition of claim 32 , wherein the composition is in tablet form.
36. The pharmaceutical composition of claim 32 , wherein the excipient is selected from the group consisting of diluents, ligands, lubricants, disintegrants, dyes, flavors and sweeteners.