CATHETER LOCK SOLUTION COMPRISING CITRATE AND A PARABEN
This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.
1 .- 39 . (canceled)
40 . An aqueous composition comprising citrate and a paraben dispersed or dissolved therein.
41 . The aqueous composition of claim 40 , wherein the paraben is methyl paraben, propyl paraben, or a combination thereof.
42 . The aqueous composition of claim 40 , wherein the composition comprises about 0.005 to about 0.5 percent (g/100 ml) methyl paraben.
43 . The aqueous composition of claim 40 , wherein the composition comprises about 0.005 to about 0.5 percent (g/100 ml) propyl paraben.
44 . The aqueous composition of claim 40 , wherein the composition comprises about 0.05 to about 0.5 percent (g/100 ml) methyl paraben, and about 0.005 to about 0.5 percent (g/100 ml) propyl paraben.
45 . The aqueous composition of claim 40 , wherein the concentration of citrate in the solution is at least as high as the calcium concentration in a patient's blood.
46 . The aqueous composition of claim 40 , wherein the concentration of citrate in the solution is from about 1.5 to about 47% by weight.
47 . The aqueous composition of claim 40 , wherein the citrate has a concentration of from about 1.5 to about 15% by weight, and the paraben has a concentration of from about 0.005 to about 0.6% percent (g/100 ml).
48 . The aqueous composition of claim 40 , wherein the citrate is trisodium citrate dihydrate.
49 . The aqueous composition of claim 40 , wherein the pH of the solution is from about 4 to about 8.
50 . The aqueous composition of claim 40 , wherein the relative density of the solution is from about 1.000 to about 1.300 g/ml.
51 . The aqueous composition of claim 40 , wherein the solution further comprises a viscosifying agent.
52 . The solution of claim 1 , further comprising alcohol.
53 . The solution of claim 40 , wherein the paraben has a concentration of about 0.1 percent to about 0.3 percent.
54 . The aqueous composition of claim 40 comprising about 0.01-1 M citrate, and about 0.005-0.6 percent (g/100 ml) paraben dispersed or dissolved therein.
55 . The solution of claim 54 , wherein the paraben has a concentration of about 0.1% to about 0.3% by weight.
56 . A method of locking a catheter comprising introducing an aqueous composition of claim 40 into a lumen of the catheter.