Biguanide compositions and methods of treating metabolic disorders
Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
1. A method of ameliorating diabetes in a patient in need thereof comprising administering to the patient a pharmaceutical dosage form comprising a therapeutically effective amount of metformin or a salt thereof and having an onset of release in the duodenum, jejunum, ileum, caecum, colon and/or rectum of the subject, wherein the average systemic bioavailability of metformin as measured by plasma AUC resulting from administration of said pharmaceutical dosage form is 70%, 60%, 50%, 40%, 30% or 20% less than the average systemic bioavailability of an immediate release formulation having an equivalent amount of said metformin or salt thereof.
2. The method according to claim 1 , wherein the circulating plasma concentration of metformin in the patient resulting from administration of said pharmaceutical dosage form is below about 1000 ng/ml.
3. The method according to claim 1 , wherein the circulating plasma concentration of metformin in the patient resulting from administration of said pharmaceutical dosage form is below about 500 ng/ml.
4. The method according to claim 1 , wherein the plasma C max level of metformin resulting from administration of said pharmaceutical dosage form is less than about 1500 ng/ml.
5. The method according to claim 1 , wherein the plasma C max level of metformin resulting from administration of said pharmaceutical dosage form is less than about 1000 ng/ml.
6. The method according to claim 1 , wherein said pharmaceutical dosage form has an onset of release at pH 5.5.
7. The method according to claim 1 , wherein said pharmaceutical dosage form has an onset of release at pH 6.0.
8. The method according to claim 1 , wherein said pharmaceutical dosage form has an onset of release at pH 6.5.
9. The method according to claim 1 , wherein said pharmaceutical dosage form has an onset of release at pH 7.0.
10. The method according to claim 1 , wherein said metformin or salt thereof is metformin hydrochloride.
11. The method according to claim 1 , wherein said pharmaceutical dosage form further comprises an immediate release component comprising an antidiabetic agent selected from the group consisting of thiazolidinediones, sulfonylureas, meglitinides, alpha-glucosidase inhibitors, DPP-IV inhibitors, and incretin mimetics.
12. The method according to claim 1 , wherein the plasma AUC of metformin resulting from administration of said pharmaceutical dosage form is 30% of the plasma AUC level resulting from administration of said immediate release formulation.
13. The method according to claim 1 , wherein the plasma AUC of metformin resulting from administration of said pharmaceutical dosage form is 40% of the plasma AUC level resulting from administration of said immediate release formulation.
14. The method according to claim 1 , wherein the plasma AUC of metformin resulting from administration of said pharmaceutical dosage form is 50% of the plasma AUC level resulting from administration of said immediate release formulation.