Phenoxy-pyrrolidine derivative and its use and compositions
View Patent ↗The present invention is directed to the compound 2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, its use as an inhibitor of stearoyl CoA desaturase and to pharmaceutical compositions containing this compound.
1. A method of treating obesity, or reducing body adiposity, comprising: administering to a subject in need thereof a therapeutically effective amount of compound of Formula I:
or a pharmaceutically acceptable salt, solvate or hydrate thereof.
2. The method of claim 1 , wherein said subject is a human.
3. The method of claim 1 , wherein said compound is administered topically, orally or parenterally.
4. A method of treating atherosclerosis, reducing serum cholesterol, reducing plasma triglycerides, or treating hypertriglyceridemia, comprising: administering to a subject in need thereof a therapeutically effective amount of compound of Formula I:
or a pharmaceutically acceptable salt, solvate or hydrate thereof.
5. The method of claim 4 , wherein said subject is a human.
6. The method of claim 4 , wherein said compound is administered topically, orally or parenterally.