IP Library Granted Patent US 8,436,179
Granted Patent B2
US 8,436,179 · App. 13/551,680 · Granted May 7, 2013

Kinase inhibitor with improved solubility profile

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Quick Facts
Patent No.
US 8,436,179
App. No.
13/551,680
Granted
May 7, 2013
Kind
B2
Abstract

4-Amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide which inhibits protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved aqueous solubility profile, compositions containing 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide and methods of treating diseases using 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide are disclosed.

Claims (2)

1. 4-Amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide; and pharmaceutically acceptable salts thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 4, 2013
From: ABBOTT LABORATORIES
To: ABBVIE INC.
Reel/Frame 030155/0886 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2013
From: ABBOTT LABORATORIES
To: ABBVIE INC.
Reel/Frame 030003/0769 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 26, 2012
From: MICHAELIDES, MICHAEL R.; CURTIN, MICHAEL L.; HOLMS, JAMES H.; STEINMAN, DOUGLAS H.
To: ABBOTT LABORATORIES
Reel/Frame 028649/0216 →