Methods and compositions comprising at least one α3 βA4 nAChR antagonist or pharmaceutically acceptable salt thereof
View Patent ↗The present invention is directed to methods and formulations for treating, modifying, and/or managing gastrointestinal secretion, and intestinal conditions that cause the same. Methods of using at least one α3 β4 nAChR antagonist and formulations comprising at least one α3 β4 nAChR antagonist, or pharmaceutically acceptable salt thereof, are included.
1. A pharmaceutical composition comprising a therapeutically-effective amount of N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine or pharmaceutically-acceptable salt thereof and at least one pharmaceutically-acceptable excipient in a modified-release formulation in a dosage form chosen from oral, intra-nasal, and transdermal forms; wherein:
N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine exhibits an IC50 value for the α3 β4 sub-type of nAChR ranging from 1.0=10-6 to 1×10-9 M or exhibits a potency for the α3 β4 nAChR sub-type at least two-times greater in comparison to at least one other nAChR sub-type;
the composition produces a peak:trough plasma level ratio of greater than zero to less than about 4:1;
the therapeutically-effective amount ranges from about 2 mg to about 12 mg per day;
the composition minimizes at least one side effect chosen from effects on heart rate, blood pressure, vision, and bladder function associated with a conventional formulation of the at least one an α3 β4 nAChR antagonist or pharmaceutically-acceptable salt thereof; and
N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine or the pharmaceutically-acceptable salt thereof is the sole active pharmaceutical compound in the composition.
2. The composition according to claim 1 , wherein the N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine comprises racemic N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, enriched (R)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, enriched (S)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, substantially pure (R)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, substantially pure (S)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, or pharmaceutically-acceptable salts of any of the foregoing.
3. The composition according to claim 2 , wherein the N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine comprises racemic N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, or a pharmaceutically-acceptable salt thereof.
4. The composition according to claim 2 , wherein the N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine comprises enriched (S)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, enriched (R)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, or pharmaceutically-acceptable salts thereof.
5. The composition according to claim 2 , wherein the N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine comprises substantially pure (S)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, substantially pure (R)—N-2,3,3-tetramethylbicyclo-[2.2.1]heptan-2-amine, or pharmaceutically acceptable salts thereof.
6. The composition according to claim 1 , wherein the composition further comprises at least one immediate-release component.
7. The composition according to claim 1 , wherein the composition comprises extended-release components, or delayed-release components, or both extended-release and delayed-release components.
8. The composition according to claim 1 , wherein the composition is chosen from a matrix formulation, an osmotic pump-based formulation, and a modified-membrane formulation.
9. The composition according to claim 1 , wherein the composition, when tested in a U.S. Pharmacopeia (USP) Type 2 Apparatus, at 37° C., stirred at 50 rpm, and in pH 6.8 phosphate buffer, releases
less than about 60% of the at least one antagonist in less than about 2 hours;
greater than or equal to about 40% in about 12 or more hours; and
about 70% or more in about 24 or more hours.
10. The composition according to claim 9 , wherein the composition releases
less than or equal to about 60% of the at least one antagonist in about 2 hours,
less than or equal to about 70% in about 4 hours;
greater than or equal to about 50% in about 8 hours;
greater than or equal to about 65% in about 12 hours; and
greater than or equal to about 80% in about 24 hours.
11. The composition according to claim 10 , wherein the composition releases
less than or equal to about 50% of the at least one antagonist in about 2 hours,
less than or equal to about 65% in about 4 hours;
greater than or equal to about 60% in about 8 hours;
greater than or equal to about 70% in about 12 hours; and
greater than or equal to about 80% in about 24 hours.
12. The composition according to claim 11 , wherein the composition releases
less than or equal to about 40% of the at least one antagonist in about 2 hours,
from about 20% to about 60% in about 4 hours;
greater than or equal to about 70% in about 8 hours;
greater than or equal to about 75% in about 12 hours; and
greater than or equal to about 80% in about 24 hours.