IP Library Granted Patent US 8,656,951
Granted Patent B2
US 8,656,951 · App. 13/554,983 · Granted Feb 25, 2014

Encapsulated valve system

Inventors: Michael C. Gagne (Mission Viejo, CA); Steven V. Cates (Corona, CA)
Assignee: Alphabio, Inc.
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Quick Facts
Patent No.
US 8,656,951
App. No.
13/554,983
Granted
Feb 25, 2014
Kind
B2
Abstract

An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.

Claims (36)

1. An encapsulated valve system for fluids comprising:

a first housing having a first facing surface, the first facing surface comprising a plurality of passageways formed therein;

a second housing having a second facing surface, the second facing surface comprising a plurality of corresponding passageways formed therein that mirror the plurality of passageways formed in the first facing surface, wherein at least one of the passageways comprises a common passageway and terminates in an inlet and an outlet and a plurality of remaining passageways comprise branch passageways branching therefrom;

a disposable conduit comprising a polymer interposed between the first housing and the second housing in the plurality of passageways;

a first pinch valve actuator mounted on the first housing portion and oriented generally perpendicular to the first facing surface and configured to pinch and close the disposable conduit at a location within the common pathway;

a plurality of pinch valve actuators mounted on the second housing portion and oriented generally perpendicular to the second facing surface and configured to pinch and close the disposable conduit at selective, different branch passageways; and

at least one removable fastener configured to hold first housing against the second housing in a facing arrangement to form a seam between the first facing surface and the second facing surface; and

further comprising at least one pinch valve actuator disposed at the seam and configured to actuate along a plane of the seam, the at least one pinch valve actuator disposed generally perpendicular to the first pinch valve actuator and the plurality of pinch valve actuators mounted on the second housing portion.

2. The encapsulated valve system of claim 1 , wherein the at least one fastener comprises a clamp.

3. The encapsulated valve system of claim 1 , wherein the at least one fastener comprises a screw.

4. The encapsulated valve system of claim 1 , wherein the first housing and second housing comprise metal.

5. The encapsulated valve system of claim 1 , wherein the first housing and second housing comprise plastic.

6. The encapsulated valve system of claim 1 , wherein the first pinch valve actuator mounted on the first housing and the plurality of pinch valve actuators mounted on the second housing comprise manually adjusted pinch valve actuators.

7. The encapsulated valve system of claim 1 , wherein the first pinch valve actuator mounted on the first housing and the plurality of pinch valve actuators mounted on the second housing comprise automatically adjusted pinch valve actuators.

8. The encapsulated valve system of claim 1 , wherein the first housing and second housing comprise a plurality of connectors disposed at locations wherein the common and branch passageways terminate.

9. The encapsulated valve system of claim 1 , wherein the conduit terminates in a sealing member.

10. The encapsulated valve system of claim 1 , wherein the conduit comprises un-reinforced tubing.

11. The encapsulated valve system of claim 10 , wherein the conduit comprises silicone.

12. An encapsulated valve system for pressurized fluids comprising:

a first metal housing having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface, wherein one of the plurality of branch pathways comprises a first aperture;

a second metal housing having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface, wherein one of the plurality of branch pathways comprises a second aperture located at a different location from the first aperture;

a disposable conduit comprising polymer tubing configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface, the disposable conduit configured to carry a pressurized fluid therein; and

a first automatically-controlled pinch valve actuator mounted on the first housing, a second automatically-controlled pinch valve actuator mounted on the second housing, wherein the first automatically-controlled pinch valve actuator is disposed on the first metal housing and oriented generally perpendicular to the first facing surface and comprises a pinching element configured to pass through the first aperture and wherein the second automatically-controlled pinch valve actuator is disposed on the second metal housing and oriented generally perpendicular to the second facing surface and comprises a pinching element configured to pass through the second aperture, wherein the first and second automatically-controlled pinch valve actuators are configured have an “on” state and an “off” state, wherein in the “off” state the pinching element of does not pass through its respective aperture and wherein in the “on” state, the pinching element passes through its respective aperture and completely closes the disposable conduit to prevent the passage of pressurized fluid therethrough.

13. A method of valving pressurized fluids comprising:

providing an encapsulated valve system for pressurized fluids comprising:

a first metal housing having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface, wherein one of the plurality of branch pathways comprises a first aperture;

a second metal housing having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface, wherein one of the plurality of branch pathways comprises a second aperture located at a different location from the first aperture;

a disposable conduit comprising polymer tubing configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface, the disposable conduit configured to carry a pressurized fluid therein;

a first automatically-controlled pinch valve actuator mounted on the first housing, wherein the first automatically-controlled pinch valve actuator is disposed on the first metal housing and oriented generally perpendicular to the first facing surface and comprises a pinching element configured to pass through the first aperture;

a second automatically-controlled pinch valve actuator mounted on the second housing, wherein the second automatically-controlled pinch valve actuator is disposed on the second metal housing and oriented generally perpendicular to the second facing surface and comprises a pinching element configured to pass through the second aperture, wherein the first and second automatically-controlled pinch valve actuators are configured have an “on” state and an “off” state, wherein in the “off” state the pinching element of does not pass through its respective aperture and wherein in the “on” state, the pinching element passes through its respective aperture and completely closes the disposable conduit to prevent the passage of pressurized fluid therethrough;

at least one removable fastener configured to secure the first housing to the second housing;

flowing a pressurized fluid through the disposable conduit and actuating the first and second pinch valve actuators;

opening the first and second housings with the at least one removable fastener;

disposing of the disposable conduit and replacing the same with a second disposable conduit;

closing the opening the first and second housings with the at least one removable fastener; and

flowing a pressurized fluid through the disposable conduit and actuating the first and second pinch valve actuators.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2024
From: ALPHINITY, LLC
To: REPLIGEN CORPORATION
Reel/Frame 068636/0413 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2020
From: ALPHINITY, LLC
To: REPLIGEN CORPORATION
Reel/Frame 054580/0754 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2015
From: ALPHABIO, INC.
To: ALPHINITY, LLC
Reel/Frame 035006/0259 →
Continuity (2)
Continuation 12466918 · May 15, 2009
Related Publication 20120279594A1 · Nov 8, 2012