Tricalcium phosphate coarse particle compositions and methods for making the same
View Patent ↗Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.
1. A method for forming a tricalcium phosphate coarse particle composition, the method comprising:
(a) converting an initial tricalcium phosphate particulate composition to hydroxyapatite;
(b) sintering the hydroxyapatite to produce a second tricalcium phosphate composition; and
(c) mechanically manipulating the second tricalcium phosphate composition to produce the tricalcium phosphate coarse particle composition.
2. The method according to claim 1 , wherein the initial tricalcium phosphate particulate composition is converted to hydroxyapatite by combining said initial tricalcium phosphate particulate composition with an alkali metal phosphate solution.
3. The method according to claim 2 , wherein the alkali metal phosphate solution is a sodium phosphate solution.
4. The method according to claim 1 , wherein after step (a), the hydroxyapatite is milled before sintering in step (b).
5. The method according to claim 1 , wherein after step (a), the hydroxyapatite is pelletized before sintering in step (b).
6. The method according to claim 1 , wherein the initial tricalcium phosphate particulate composition is prepared by:
(a) combining dicalcium phosphate anhydrous, calcite and water to produce a paste composition;
(b) sintering the paste composition to produce a sintered product; and
(c) mechanically disrupting the sintered product to produce said initial tricalcium phosphate particulate composition.
7. The method according to claim 1 , wherein the tricalcium phosphate coarse particle composition comprises α-tricalcium phosphate particles.
8. The method according to claim 1 , wherein the method yields a composition that is 25% or more coarse particles.
9. The method according to claim 1 , wherein the method yields a composition that is 50% or more coarse particles.
10. The method according to claim 1 , wherein said method yields a composition that is 60% or more coarse particles.
11. The method according to claim 1 , wherein said method yields a composition that is 80% or more coarse particles.
12. The method according to claim 1 , wherein the tricalcium phosphate coarse particle composition comprises particles ranging in size from 38 to 212 μm.
13. The method according to claim 1 , wherein the sintering comprises heating said hydroxyapatite to temperature ranging from 1300 to 1500° C.
14. The method according to claim 1 , wherein the tricalcium phosphate coarse particle composition comprises particles that are 95-97% α-TCP.