Long circulating nanoparticles for sustained release of therapeutic agents
View Patent ↗The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
1. A sterile, biocompatible, injectable nanoparticle composition comprising a plurality of long circulating nanoparticles having a diameter of about 70 to about 130 nm, each of the plurality of the long circulating nanoparticles comprising:
about 70 to about 90 weight percent poly(lactic) acid-co-poly(ethylene) glycol, wherein the weight ratio of poly(lactic) acid to poly(ethylene) glycol is about 15 kDa/2 kDa to about 20 kDa/10 kDa, and
a therapeutic agent encapsulated in the nanoparticles,
said composition providing an elevated plasma concentration of the therapeutic agent for at least 24 hours when the composition is administered to a patient, to provide:
an area under the plasma concentration time curve (AUC) that is increased by at least 500% over the AUC provided when the equivalent dosage of the therapeutic agent is intravenously administered in a non-nanoparticle to a patient;
an actual peak plasma concentration (Cmax) that is at least 100% higher as compared to a Cmax of said therapeutic when the therapeutic agent is intravenously administered in a non-nanoparticle to the patient; and
a volume of distribution (Vz) that is about the patient's plasma volume upon intravenous administration of the composition.
2. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , wherein each of the plurality of nanoparticles comprise about 5 to about 25 weight percent therapeutic agent.
3. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , wherein the weight ratio of poly(lactic) acid to poly(ethylene)glycol in each of the plurality of nanoparticles is about 15 kDa/4 kDa to about 20 kDa/6 kDa.
4. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , wherein the weight ratio of poly(lactic) acid to poly(ethylene)glycol in each of the plurality of nanoparticles is about 16 kDa/5 kDa.
5. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , wherein the composition is an aqueous solution further comprising a saccharide.
6. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , wherein the patient is a mammal.
7. A method of treating a solid tumor cancer, comprising administering the nanoparticle composition of claim 1 , to a patient in need thereof.
8. The method of claim 7 , wherein at least 24 hours after administration, the solid tumor has significant concentration of therapeutic agent.
9. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , further comprising a surfactant.
10. The sterile, biocompatible, injectable nanoparticle composition of claim 9 , wherein the surfactant is polysorbate 80.
11. The sterile, biocompatible, injectable nanoparticle composition of claim 1 , wherein therapeutic agent is a chemotherapeutic agent.
12. A sterile, biocompatible, injectable nanoparticle composition comprising a plurality of long circulating nanoparticles, each long circulating nanoparticle comprising:
about 70 to about 90 weight percent of an α-hydroxy polyester-co-polyether comprising a weight ratio of about 16/5 polylactic acid-polyethylene glycol, and docetaxel, said composition providing an elevated plasma concentration of docetaxel for at least 24 hours when the composition is administered to a patient.