IP Library › Granted Patent US 8,686,163
Granted Patent B2
US 8,686,163 · App. 13/559,776 · Granted Apr 1, 2014

Process for forming amorphous atorvastatin

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Quick Facts
Patent No.
US 8,686,163
App. No.
13/559,776
Granted
Apr 1, 2014
Kind
B2
Abstract

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

Claims (4)

1. A process for forming amorphous atorvastatin comprising:

(a) dissolving atorvastatin and optionally an excipient in a solvent, dimethyl sulfoxide, to form a solution; and

(b) lyophilizing the solution to afford amorphous atorvastatin.

2. The process of claim 1 wherein the excipient is selected from the group consisting of: a solubilizing agent; an alkalizing agent; an antioxidant; and mixtures thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2020
From: PFIZER INC.
To: UPJOHN US 1 LLC
Reel/Frame 054293/0154 →