Silicone-based composition for skin treatment
The present embodiments may relate to topically delivered compounded medications for the treatment of scar tissue, skin disorders, and/or other ailments. In one aspect, a transdermal cream or gel may provide for the effective administration of multiple medications simultaneously. Preferably, a silicone-based gel may be provided as a base composition and may have a non-zero percentage of silicone or silicone variant. The silicone-based gel may comprise cyclopentasiloxane, polysilicone-11, dimethicone, and C30-45 alkyl cetearyl dimethicone crosspolymer, and include several active ingredients, such as glucocorticoids, antihistamines, and nerve depressants. The silicone-based gel may include a combination of fluticasone, loratadine, and gabapentin. The concentrations of fluticasone and loratadine may be relatively low, while that of gabapentin moderately high. The silicone-based gel may also have one or more local anesthetics, such as prilocaine and/or lidocaine. The silicone-based gel may include additional active ingredients, such as NSAIDs, anticonvulsants, antidepressants, muscle relaxants, and/or other active ingredients.
1. A silicone-based gel for topical application and treatment of scar tissue, the silicone-based gel comprising:
cyclopentasiloxane, polysilicone-11, dimethicone and C30-45 alkyl cetearyl dimethicone crosspolymer;
a first active ingredient in a first amount of between approximately 0.1% and approximately 5.0% by weight of the silicone-based gel, the first active ingredient comprising a fluticasone;
a second active ingredient in a second amount of between approximately 0.1% and approximately 5.0% by weight of the silicone-based gel, the second active ingredient comprising loratadine;
a third active ingredient in a third amount of between approximately 5.0% and approximately 25.0% by weight of the silicone-based gel, the third active ingredient comprising gabapentin; and
lidocaine and prilocaine each in an amount of between approximately 1.0% and approximately 7.0% by weight of the silicone-based gel,
wherein the topical application of the silicone-based gel allows for transdermal administration of the active ingredients simultaneously.
2. The silicone-based gel of claim 1 , wherein the silicone-based gel further comprises at least approximately 50% silicone or silicone variant.
3. The silicone-based gel of claim 1 , wherein the silicone-based gel further comprises a fourth active ingredient in a fourth amount of between approximately 0.05% and approximately 5.0% by weight of the silicone-based gel, the fourth active ingredient comprising a NSAID (Non-Steroidal Anti-Inflammatory Drug) or an anticonvulsant.
4. The silicone-based gel of claim 1 , comprising fluticasone in an amount between approximately 0.1% and approximately 2.0% by weight of the silicone-based gel; loratadine in an amount between approximately 1.0% and approximately 3.0% by weight of the silicone-based gel, gabapentin in an amount between approximately 10.0% and approximately 20.0% by weight of the silicone-based gel; and lidocaine and prilocaine each in an amount between approximately 2.0% and approximately 4.0% by weight of the silicone-based gel.
5. The silicone-based gel of claim 1 , comprising approximately 1.0% fluticasone by weight of the silicone-based gel; approximately 2.0% loratadine by weight of the silicone-based gel; approximately 15.0% gabapentin by weight of the silicone-based gel; and lidocaine and prilocaine each in an amount between approximately 3.0% by weight of the silicone-based gel.
6. The silicone-based gel of claim 1 , further comprising tocopheryl acetate.