Biocompatible and biodegradable elastomeric polymers

1. A biocompatible polymer comprising:

a) one or more ECM-mimetic peptides having the amino acid sequence GVGVP as set forth in SEQ ID NO: 29; and

b) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;

wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da.

2. A biocompatible polymer comprising:

a) one or more ECM-mimetic peptides; and

b) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;

wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da having the formula:

wherein:

Mim is the ECM-mimetic peptide having the formula:

-[Xaa-Xbb-Xcc] x ; or

-[Xaa-Xbb-Xcc-Xdd] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee-Xff] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee-Xff-Xgg] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee-Xff-Xgg-Xhh] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee-Xff-Xgg-Xhh-Xii] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee-Xff-Xgg-Xhh-Xii-Xjj] x ; or

-[Xaa-Xbb-Xcc-Xdd-Xee-Xff-Xgg-Xhh-Xii-Xjj-Xkk] x;

wherein:

at least one of Xaa, Xbb, Xcc, Xdd, Xee, Xff, Xgg, Xhh, Xii, Xjj, and Xkk is a proline residue; the balance of Xaa, Xbb, Xcc, Xdd, Xee, Xff, Xgg, Xhh, Xii, Xjj, and Xkk are independently chosen from glycine, alanine, valine, leucine, and isoleucine;

wherein BioDeg is the non-amino acid or residue thereof containing one or more biodegradable moieties;

the index x is an integer from 1 to 30;

the index y is an integer from 1 to 10;

the index z is an integer from 1 to 2000;

wherein L is a biodegradable or non-biodegradable linker;

and wherein the one or more ECM-mimetic peptides are chosen from:

[SEQ ID NO: 61]

i)

Gly- Val-Pro-Gly-Val-Gly -Gly;

[SEQ ID NO: 62]

ii)

Pro-Gly- Val-Pro-Gly-Val-Gly -Gly;

[SEQ ID NO: 63]

iii)

Gly- Val-Pro-Gly-Val-Gly -Leu-Ala;

[SEQ ID NO: 64]

iv)

Val-Gly- Val-Pro-Gly-Val-Gly -Ile-Gly;

[SEQ ID NO: 65]

v)

Gly-Val-Gly- Val-Pro-Gly-Val-Gly -Gly;

[SEQ ID NO: 66]

vi)

Gly- Val-Pro-Gly-Val-Gly -Leu-Leu;

[SEQ ID NO: 67]

vii)

Gly-Gly-Gly- Val-Pro-Gly-Val-Gly -Gly-Gly;

[SEQ ID NO: 68]

viii)

Gly-Gly- Val-Pro-Gly-Val-Gly -Gly-Ala-Ala;

[SEQ ID NO: 69]

ix)

Pro-Pro-Gly- Val-Pro-Gly-Val-Gly -Gly-Gly-

Pro;

[SEQ ID NO: 70]

x)

Ala- Val-Pro-Gly-Val-Gly -Ala;

[SEQ ID NO: 71]

xi)

Ala-Ala- Val-Pro-Gly-Val-Gly -Ala;

[SEQ ID NO: 72]

xii)

Ala- Val-Pro-Gly-Val-Gly -Ala-Ala;

[SEQ ID NO: 73]

xiii)

Ala-Ala- Val-Pro-Gly-Val-Gly -Ala-Ala;

[SEQ ID NO: 74]

xiv)

Ala-Leu-Ala- Val-Pro-Gly-Val-Gly -Ala;

[SEQ ID NO: 75]

xv)

Ala- Val-Pro-Gly-Val-Gly -Ala-Ile-Ile;

[SEQ ID NO: 76]

xvi)

Gly-Val-Gly- Val-Pro-Gly-Val-Gly -Gly-Val;

[SEQ ID NO: 77]

xvii)

Ala-Ala- Val-Pro-Gly-Val-Gly -Ala-Ala-Ala;

[SEQ ID NO: 78]

xviii)

Ala-Ala-Ala- Val-Pro-Gly-Val-Gly -Ala-Ala-

Ala;

and

[SEQ ID NO: 29]

xix)

Gly-Val-Gly-Val-Pro;.

3. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is an integer from 1 to 10.

4. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is from 1 to 10.

5. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is from 1 to 10.

6. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is from 1 to 10.

7. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is from 1 to 10.

8. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is from 1 to 10.

9. The polymer according to claim 2 , wherein the linker has the formula:

and the index t is from 1 to 10.

10. A method for preparing a biocompatible polymer comprising:

i) one or more ECM-mimetic peptides having the amino acid sequence GVGVP as set forth in SEQ ID No: 29; and

ii) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;

wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da,

comprising:

a) providing an ECM-mimetic peptide-comprising reagent having the formula:

H 2 N-G-V-G-V-P-OH [SEQ ID No: 29];

b) coupling a biodegradable reagent that does not comprise an amino acid or residue thereof to the ECM-mimetic peptide-comprising reagent of step (a); and

c) polymerizing the product of step (b).

11. A method for preparing a biocompatible polymer comprising:

i) one or more ECM-mimetic peptides having the amino acid sequence GVGVP as set forth in SEQ ID No: 29; and

ii) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;

wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da,

comprising:

a) providing an ECM-mimetic peptide-comprising reagent having the formula:

H 2 N-(G-V-G-V-P) x -OH [SEQ ID No: 29];

and the index x is an integer from 1 to 100;

b) coupling a biodegradable reagent that does not comprise an amino acid or residue thereof to the ECM-mimetic peptide-comprising reagent of step (a); and

c) polymerizing the product of step (b).

12. An article comprising the biocompatible polymer of claim 2 .

13. The article of claim 12 , wherein the article is a stent, implant, film, foam, sponge, patch, matrix, fabric, mesh, membrane, or felt.

14. The article of claim 12 , wherein the article is a stent that is coated with the biocompatible polymer.

15. The article of claim 14 , further comprising a bioactive agent.