IP Library › Granted Patent US 8,597,687
Granted Patent B2
US 8,597,687 · App. 13/569,095 · Granted Dec 3, 2013

Methods for determining the orientation of a tissue graft

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Quick Facts
Patent No.
US 8,597,687
App. No.
13/569,095
Granted
Dec 3, 2013
Kind
B2
Abstract

A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

Claims (7)

1. A method for permitting direct, visual determination of the orientation of a placental tissue graft by user, wherein the placental tissue graft has a first side and a second side, said method comprising: placing an asymmetric label on a portion of at least one side of said tissue graft, which label visibly distinguishes one side from the other side, thereby permitting direct, visual determination of the orientation for application of said tissue graft; and ascertaining the orientation of the placental tissue graft by direct visual determination.

2. The method of claim 1 , wherein said label is an embossment.

3. The method of claim 1 , wherein said label is a raised or indented texture.

4. The method of claim 1 , wherein said label is a logo, a design, a name, or text.

5. The method of claim 1 , wherein said tissue graft contains multiple tissue layers.

6. The method of claim 1 , wherein said label visibly distinguishes a basement side of the placental tissue graft.

7. The method of claim 1 , wherein said label visibly distinguishes a stromal side of the placental tissue graft.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Jul 2, 2020
From: BLUE TORCH FINANCE LLC, AS COLLATERAL AGENT
To: MIMEDX GROUP, INC.; MIMEDX PROCESSING SERVICES, LLC
Reel/Frame 054075/0687 →
SECURITY INTEREST Recorded Jun 11, 2019
From: MIMEDX GROUP, INC.
To: BLUE TORCH FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 049426/0863 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 24, 2019
From: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
To: MIMEDX GROUP, INC.
Reel/Frame 048121/0835 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Oct 15, 2015
From: MIMEDX GROUP, INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 036872/0498 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2013
From: DANIEL, JOHN
To: SURGICAL BIOLOGICS, LLC.
Reel/Frame 030397/0762 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2013
From: SURGICAL BIOLOGICS, LLC.
To: MIMEDX GROUP, INC.
Reel/Frame 030397/0794 →