IP Library › Granted Patent US 8,636,637
Granted Patent B2
US 8,636,637 · App. 13/571,495 · Granted Jan 28, 2014

Methods for asymmetrical irradiation of a body cavity

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,636,637
App. No.
13/571,495
Granted
Jan 28, 2014
Kind
B2
Abstract

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

Claims (23)

1. An apparatus for treating tissue surrounding a body cavity of a patient with a radiation source, comprising:

an elongate outer catheter having a distal end, a treatment portion proximal the distal end, and a first lumen configured to extend into the treatment portion; and

an elongate inner catheter positioned in the first lumen of the outer catheter, the elongate inner catheter having a longitudinal axis and an off-set lumen off-set in its entirety from the longitudinal axis, the elongate inner catheter being configured to extend within the first lumen into the treatment portion of the elongate outer catheter and configured to rotate relative to the elongate outer catheter about the longitudinal axis, the off-set lumen of the elongate inner catheter being configured to receive the radiation source.

2. The apparatus of claim 1 , comprising an inflatable member coupled to the outer elongate catheter and positioned to surround the treatment portion.

3. The apparatus of claim 2 , wherein the elongate outer catheter has an annular wall and an inflation lumen located in the annular wall, the inflation lumen being configured in fluid communication with an interior of the inflatable member.

4. The apparatus of claim 3 , comprising:

a first vacuum port located in the elongate outer cannula proximal to the inflatable member and configured in fluid communication with a region exterior to the elongate outer cannula; and

a first vacuum lumen located in the annular wall, and configured in fluid communication with the first vacuum port.

5. The apparatus of claim 4 , comprising:

a second vacuum port located in the elongate outer cannula distal to the inflatable member and configured in fluid communication with the region exterior to the elongate outer cannula; and

a second vacuum lumen located in the annular wall, and configured in fluid communication with the second vacuum port.

6. The apparatus of claim 3 , wherein the elongate inner catheter includes a central lumen that extends along the longitudinal axis and is configured to receive the radiation source.

7. A brachytherapy device for treating tissue surrounding a body cavity of a patient with a radiation source, comprising:

an elongate outer catheter having a distal end, a treatment portion proximal the distal end, and a first lumen configured to extend into the treatment portion; and

an elongate inner catheter positioned in the first lumen of the outer catheter, the elongate inner catheter having a longitudinal axis, a central lumen that extends along the longitudinal axis, and an off-set lumen off-set in its entirety from the longitudinal axis, each of the central lumen and the off-set lumen being configured to extend the treatment portion in the outer catheter, and elongate inner catheter configured to rotate relative to the elongate outer catheter about the longitudinal axis, each of the central lumen and off-set lumen of the elongate inner catheter being configured to receive the radiation source.

8. The brachytherapy device of claim 7 , comprising an inflatable member coupled to the outer elongate catheter and positioned to surround the treatment portion.

9. The brachytherapy device of claim 8 , wherein the elongate outer catheter has an annular wall and an inflation lumen located in the annular wall, the inflation lumen being configured in fluid communication with an interior of the inflatable member.

10. The brachytherapy device of claim 9 , comprising:

a first vacuum port located in the elongate outer cannula proximal to the inflatable member and configured in fluid communication with a region exterior to the elongate outer cannula; and

a first vacuum lumen located in the annular wall, and configured in fluid communication with the first vacuum port.

11. The brachytherapy device of claim 10 , comprising:

a second vacuum port located in the elongate outer cannula distal to the inflatable member and configured in fluid communication with the region exterior to the elongate outer cannula; and

a second vacuum lumen located in the annular wall, and configured in fluid communication with the second vacuum port.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE R/F 030755 0031 Recorded Jul 17, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 036127/0538 →
SECURITY AGREEMENT Recorded Jul 9, 2013
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE, INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 030755/0031 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2013
From: SENORX, INC.
To: HOLOGIC, INC.
Reel/Frame 030530/0229 →