Method for treatment of post operative cognitive dysfunction
The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided.
1. A method for the treatment or prophylaxis of post operative cognitive dysfunction (POCD) in a patient following surgery in said patient, the method comprising administering a therapeutically effective amount of an anti-Tumour Necrosis Factor alpha (anti-TNFα) antibody and a therapeutically effective amount of an Interleukin 1 (IL-1) receptor antagonist to said patient.
2. The method according to claim 1 , wherein the anti-TNFα antibody and the IL-1 receptor antagonist are administered to the patient, before commencement of a surgical procedure; during a surgical procedure; and/or after completion of a surgical procedure, on said patient.
3. The method according to claim 2 , wherein the anti-TNFα antibody and the IL-1 receptor antagonist are administered immediately before and/or up to 1 hour after completion of said surgical procedure.
4. The method according to claim 1 , which is for preventing or reducing post operative cognitive dysfunction (POCD) when the patient is at risk of developing at least one of delirium, Alzheimer's Disease, multiple sclerosis, stroke, Parkinson's Disease, Huntington's Disease, dementia, frontotemporal dementia, vascular dementia, HIV dementia, Post-Traumatic Stress Disorder and/or Rheumatoid Arthritis.
5. The method according to claim 1 , wherein the patient is a human.