Oligomer modified diaromatic substituted compounds

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Quick Facts

Patent No.: US 9,226,970
App. No.: 13/580,580
Granted: Jan 5, 2016
Kind: B2

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Abstract

Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) (PEG) oligomers. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over non-oligomer modified diaromatic substituted compounds.

Claims (15)

1. A compound having the following structure,

wherein n is an integer between 1 and 30, inclusive, and pharmaceutical salts thereof.

2. The compound of claim 1 , wherein n is an integer between 1 and 10.

3. A composition comprising (i) a compound of claim 1 , and (ii) a pharmaceutically acceptable excipient.

4. A composition of matter comprising a compound of claim 1 present in a dosage form.

5. A compound of claim 1 , wherein n is 1.

6. A compound of claim 1 , wherein n is 2.

7. A compound of claim 1 , wherein n is 3.

8. A compound of claim 1 , wherein n is 4.

9. A compound of claim 1 , wherein n is 5.

10. A compound of claim 1 , wherein n is 6.