Methods for treating multiorgan, systemic degos' disease with a complement inhibitor
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and/or an inhibitor of interferon alpha, and the use of the compositions in methods for treating or preventing Degos' disease in a subject. In some embodiments, the inhibitor is an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or to a biologically-active fragment of C5 such as C5a or C5b. In some embodiments, the inhibitor is an antibody, or an antigen-binding fragment thereof, that binds to interferon alpha or to an interferon alpha receptor.
1. A method for treating a patient afflicted with Degos' disease, the method comprising administering an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein, to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.
2. The method of claim 1 , wherein the antibody, or antigen-binding fragment thereof, is chronically administered to the patient.
3. The method of claim 1 , wherein the Degos' disease is associated with a B19 parvoviral infection or human immunodeficiency virus infection.
4. The method of claim 1 , wherein the Degos' disease is idiopathic.
5. The method of claim 1 , wherein the Degos' disease pathologically affects the gastrointestinal tract, the central nervous system, or the cardiovascular system.
6. The method of claim 1 , wherein the Degos' disease is refractory to at least one therapy selected from the group consisting of an anti-inflammatory agent, an anticoagulant, an antithrombotic, and intravenous immunoglobulin.
7. The method of claim 1 , wherein the antibody, or antigen or antigen binding fragment thereof, inhibits the cleavage of complement component C5 into fragments C5a and C5b.
8. The method of claim 1 , wherein the antibody, or antigen-binding fragment thereof, is selected from the group consisting of a humanized antibody, a recombinant antibody, a diabody, a chimerized or chimeric antibody, a deimmunized human antibody, a fully human antibody, a single chain antibody, an Fv fragment, an Fd fragment, an Fab fragment, an Fab′fragment, and an F(ab′) 2 fragment.
9. The method of claim 1 , wherein the antibody is eculizumab.
10. The method of claim 1 , wherein the antibody is pexelizumab.
11. The method of claim 1 , further comprising administering to the patient an inhibitor of interferon alpha.
12. The method of claim 11 , wherein the inhibitor of interferon alpha is an antibody, or an antigen-binding fragment thereof, that binds to interferon alpha or an interferon alpha receptor.
13. A method for treating a patient afflicted with Degos' disease, the method comprising administering eculizumab to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.
14. A method for treating a patient afflicted with Degos' disease, the method comprising administering pexelizumab to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.
15. A method for treating a patient afflicted with Degos' disease, the method comprising administering a complement inhibitor to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease, wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain, and wherein the complement inhibitor is selected from the group consisting of soluble CR1, LEX-CR1, MCP, DAF, CD59, Factor H, cobra venom factor, FUT-175, complestatin, and K76 COOH.
16. The method of claim 13 , wherein eculizumab is chronically administered to the patient.
17. The method of claim 14 , wherein pexelizumab is chronically administered to the patient.
18. The method of claim 15 , wherein the complement inhibitor is chronically administered to the patient.