SANDALWOOD OIL AND ITS USES
Provided herein are compositions of sandalwood oil and methods of making and using such compositions.
1 . A method of treating a non-skin cancer in a subject, said method comprising administering to the subject an effective amount of a composition comprising sandalwood oil, wherein the subject has a non-skin cancer.
2 . The method of claim 1 , wherein the sandalwood oil is from Santalum album or Santalum spicatum or a combination thereof.
3 . The method of claim 1 , wherein the sandalwood oil is from Santalum album.
4 . The method of claim 1 , wherein the composition comprising sandalwood oil further comprises one or more pharmaceutically acceptable excipients.
5 . The method of claim 1 , where the sandalwood oil comprises at least one of the components listed in Table 1 or a derivative thereof.
6 . The method of claim 1 , wherein the non-skin cancer is selected from the group consisting of a breast cancer, a head and neck cancer, an ovarian cancer, a bladder cancer, a prostate cancer, a lung cancer, a renal cancer, a leukemia, a liver cancer, a pancreatic cancer, a colon cancer, and a central nervous system cancer.
7 . The method of claim 3 , wherein the non-skin cancer is selected from the group consisting of a breast cancer, a head and neck cancer, an ovarian cancer, a bladder cancer, a prostate cancer, a lung cancer, a renal cancer, a leukemia, a liver cancer, a pancreatic cancer, a colon cancer, and a central nervous system cancer.
8 . The method of claim 4 , wherein the non-skin cancer is selected from the group consisting of a breast cancer, a head and neck cancer, an ovarian cancer, a bladder cancer, a prostate cancer, a lung cancer, a renal cancer, a leukemia, a liver cancer, a pancreatic cancer, a colon cancer, and a central nervous system cancer.
9 . A method of preventing the progression of actinic keratosis to squamous cell carcinoma (SCC) in a subject, comprising administering to a subject an effective amount of a composition comprising sandalwood oil, wherein the subject has actinic keratosis.
10 . The method of claim 1 , wherein the composition comprises about 1-300 micromolar sandalwood oil.
11 . The method of claim 1 , wherein the composition comprises about 0.0002-0.02% sandalwood oil (w/w).
12 . The method of claim 1 , wherein the composition comprises a concentration of sandalwood oil that is less toxic than the same concentration of cinnamon oil in a cell.
13 . The method of claim 12 , wherein the cell is a human MRC5 cell.
14 . The method of claim 12 , wherein the concentration is about 0.0002-0.02% (w/w).