IP Library › Granted Patent US 9,333,174
Granted Patent B2
US 9,333,174 · App. 13/588,549 · Granted May 10, 2016

Use of simple amino acids to form porous particles

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Quick Facts
Patent No.
US 9,333,174
App. No.
13/588,549
Granted
May 10, 2016
Kind
B2
Abstract

Particles having a tap density of less than 0.4 g/cm 3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.

Claims (10)

1. Spray dried particles consisting of a therapeutic, prophylactic or diagnostic agent, or any combination thereof, an amino acid or salt thereof;

wherein the particles have a tap density less than about 0.4 g/cm 3 and wherein the the amino acid is present in the particles in an amount of at least 10% weight.

2. The particles of claim 1 , wherein the particles have a median geometric diameter of between about 5 micrometers and about 30 micrometers.

3. The particles of claim 1 , wherein the particles have an aerodynamic diameter of between about 1 and about 5 microns.

4. The particles of claim 1 , wherein the particles have an aerodynamic diameter of between about 1 and about 3 microns.

5. The particles of claim 1 , wherein the particles have an aerodynamic diameter of between about 3 and 5 microns.

6. The particles of claim 1 , wherein the amino acid is hydrophobic.

7. The particles of claim 6 , wherein the hydrophobic amino acid is selected form the group consisting of leucine, isoleucine, alanine, valine, phenylalanine and any combination thereof.

8. The particles of claim 1 , wherein the therapeutic, prophylactic or diagnostic agent is present in the particles in an amount ranging from about 1 to about 90% weight.

9. The particles of claim 1 wherein the therapeutic agent is selected from the group consisting of: vasoactive agents, neuroactive agents, hormones, anticoagulants, immunomodulating agents, cytotoxic agents, antibiotics, antivirals, antisense molecules and antibodies.