Pharmaceutical composition of nanoparticles
View Patent ↗The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
1. A composition of nanoparticles, said nanoparticles consisting of a shell portion that is dominated by positively charged chitosan, and a core portion that consists of said positively charged chitosan, one negatively charged substrate, and optionally a zero-charge compound or at least one antihemorrhagic agent.
2. The composition according to claim 1 , wherein said chitosan is N-trimethyl chitosan, EDTA-chitosan, low molecular weight chitosan, pegylated chitosan (PEG-chitosan), mono-N-carboxymethyl chitosan, N-palmitoyl chitosan (NPCS), chitosan derivatives, or combinations thereof.
3. The composition according to claim 1 , wherein said negatively charged substrate is PGA-complexone conjugate, γ-PGA, α-PGA, derivatives of PGA, or salts of PGA.
4. The composition according to claim 1 , wherein said nanoparticles are freeze-dried, thereby said nanoparticles being in a powder form.
5. The composition according to claim 1 , wherein said nanoparticles are mixed with a cryoprotectant and then freeze-dried, thereby said nanoparticles being in a powder form.
6. The composition according to claim 5 , wherein said cryoprotectant is selected from the group consisting of trehalose, hexan-1,2,3,4,5,6-hexyl, mannitol, dimethyl sulfoxide, ethylene glycol, glycol, 2-methyl-2,4-pentanediol, propylene, sucrose, and combinations thereof.
7. The composition according to claim 1 , wherein said core portion further comprises a second antihemorrhagic agent that is loaded outside the nanoparticles.
8. The composition according to claim 1 , wherein said core portion further comprises a pharmaceutically acceptable carrier, diluent, excipient, desiccant, solubilizer, surfactants, bubbling agent, or emulsifier.
9. The composition according to claim 1 , wherein said nanoparticles are treated with an enteric coating.
10. The composition according to claim 1 , wherein said composition is administered via an oral route.
11. The composition according to claim 1 , wherein said composition is administered via a parenteral route.
12. The composition according to claim 1 , wherein said composition is administered topically.
13. The composition according to claim 1 , wherein said antihemorrhagic agent is selected from the group consisting of antifibrinolytics, vitamin K, fibrinogen, and blood coagulation factors.
14. The composition according to claim 1 , wherein said composition of nanoparticles is a granular powder being poured on wounds.
15. The composition according to claim 1 , wherein said composition of nanoparticles is embedded in a dressing.
16. The composition according to claim 1 , wherein the nanoparticles have a mean particle size between about 50 and 500 nanometers.
17. The composition according to claim 1 , wherein the nanoparticles are formed via a simple and mild ionic-gelation process.
18. The composition according to claim 1 , wherein the nanoparticles are encapsulated in a capsule.
19. The composition according to claim 18 , wherein said capsule is treated with an enteric coating polymer.