Forms of rifaximin and uses thereof
View Patent ↗The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them.
1. A method for producing a polymorph Form ζ of rifaximin, comprising the steps of:
forming an ethanol slurry of Form α-dry of rifaximin;
maintaining the slurry at ambient temperature for about three days; and
crystallizing rifaximin from the slurry;
wherein the polymorph exhibits an X-ray powder diffraction pattern having characteristics peaks expressed in degrees 2θ(+/−0.20 degree θ) at:
4.7, 7.6 and 9.5; or
4.7, 7.3 and 8.2; or
7.6, 8.6, and 10.5; or
8.2, 8.6 and 9.5; or
10.2, 12.6, and 13.2; or
7.3, 10.5, and 12.9; or
7.3, 7.6, 8.2 and 8.6; or
4.7, 7.3, 7.6, 9.5, and 10.5; or
8.2, 8.6, 9.5, 10.2, and 10.5; or
8.6, 9.5, 10.2, 10.5, and 11.2; or
4.7 6.3, 6.4, 7.3, 7.6, 8.2, 8.6, 9.5, 10.2, 10.5, 11.2, 11.9, 12.2, 12.6, 12.9, and 13.2.
2. The method of claim 1 , wherein the ethanol slurry has a ratio of ethanol:water of from between 1:0.02 to 1:0.1.
3. A method for producing a polymorph Form η of rifaximin, comprising the steps of:
forming an ethanol slurry of Form α-dry of rifaximin;
maintaining the slurry at ambient temperature for about three days;
crystallizing rifaximin from the slurry; and
drying the crystallized rifaximin;
wherein the polymorph exhibits an X-ray powder diffraction pattern having characteristics peaks expressed in degrees 2θ(+/−0.20 degree θ) at:
6.1, 7.3, and 7.5; or
6.1, 7.3, and 7.9; or
6.1, 7.3, and 8.8; or
6.1, 7.3, and 12.7; or
6.1, 7.5, and 8.8; or
6.1, 7.5, and 7.9; or
5.3, 6.1, and 7.3; or
5.3, 6.1 and 7.9; or
5.3, 6.1 and 12.7; or
5.3, 6.1, and 7.5; or
5.3, 6.1 and 8.8; or
6.1, 7.3, 7.5, 7.9, 8.8 and 12.7; or
5.3, 6.1, 7.3, 7.5, 7.9, 8.8, and 12.7; or
5.3, 6.1, 7.3, 7.9, 8.8, and 12.7; or
5.3, 6.1, 7.3, 7.5, 8.8, and 12.7; or
5.3, 6.1, 7.3, 7.5, 7.9, 8.8, and 12.7.
4. The method of claim 3 , wherein the ethanol slurry has a ratio of ethanol:water of from between 1:0.02 to 1:0.1.
5. The method of claim 3 , wherein the rifaximin is dried at ambient temperature.
6. The method of claim 3 , wherein the rifaximin is dried at a temperature of about 45° C.
7. A method for producing a polymorph Form ζ of rifaximin, comprising the steps of:
forming an ethanol and water slurry of Form α-dry of rifaximin; and
crystallizing rifaximin from the slurry, wherein the ethanol slurry has a ratio of ethanol:water of from between 1:0.02 to 1:0.45;
wherein the polymorph exhibits an X-ray powder diffraction pattern having characteristics peaks expressed in degrees 2θ(+/−0.20 degree θ) at:
4.7, 7.6 and 9.5; or
4.7, 7.3 and 8.2; or
7.6, 8.6, and 10.5; or
8.2, 8.6 and 9.5; or
10.2, 12.6, and 13.2; or
7.3, 10.5, and 12.9; or
7.3, 7.6, 8.2 and 8.6; or
4.7, 7.3, 7.6, 9.5, and 10.5; or
8.2, 8.6, 9.5, 10.2, and 10.5; or
8.6, 9.5, 10.2, 10.5, and 11.2; or
4.7 6.3, 6.4, 7.3, 7.6, 8.2, 8.6, 9.5, 10.2, 10.5, 11.2, 11.9, 12.2, 12.6, 12.9, and 13.2.
8. A method for producing a polymorph Form η of rifaximin, comprising the steps of:
forming an ethanol and water slurry of Form α-dry of rifaximin;
crystallizing rifaximin from the slurry; and
drying the crystallized rifaximin, wherein the ethanol slurry has a ratio of ethanol:water of from between 1:0.02 to 1:0.45;
wherein the polymorph exhibits an X-ray powder diffraction pattern having characteristics peaks expressed in degrees 2θ(+/−0.20 degree θ) at:
6.1, 7.3, and 7.5; or
6.1, 7.3, and 7.9; or
6.1, 7.3, and 8.8; or
6.1, 7.3, and 12.7; or
6.1, 7.5, and 8.8; or
6.1, 7.5, and 7.9; or
5.3, 6.1, and 7.3; or
5.3, 6.1 and 7.9; or
5.3, 6.1 and 12.7; or
5.3, 6.1, and 7.5; or
5.3, 6.1 and 8.8; or
6.1, 7.3, 7.5, 7.9, 8.8 and 12.7; or
5.3, 6.1, 7.3, 7.5, 7.9, 8.8, and 12.7; or
5.3, 6.1, 7.3, 7.9, 8.8, and 12.7; or
5.3, 6.1, 7.3, 7.5, 8.8, and 12.7; or
5.3, 6.1, 7.3, 7.5, 7.9, 8.8, and 12.7.
9. A polymorph Form ζ of rifaximin made according to the method of claim 1 .
10. The polymorph form of rifaximin of claim 9 , wherein the polymorph contains less than 5% by weight total impurities.
11. A polymorph Form η of rifaximin made according to the method of claim 3 .
12. The polymorph form of rifaximin of claim 11 , wherein the polymorph contains less than 5% by weight total impurities.
13. A polymorph Form ζ of rifaximin made according to the method of claim 7 .
14. The polymorphic form of rifaximin of claim 7 , wherein the polymorph contains less than 5% by weight total impurities.
15. A polymorph Form η of rifaximin made according to the method of claim 8 .
16. The polymorph form of rifaximin of claim 15 , wherein the polymorph contains less than 5% by weight total impurities.
17. The polymorph form of rifaximin of claim 9 , wherein the form is at least 50% pure, or at least 75% pure, or at least 80% pure, or at least 90% pure, or at least 95% pure, or at least 98% pure.
18. The polymorph form of rifaximin of claim 11 , wherein the form is at least 50% pure, or at least 75% pure, or at least 80% pure, or at least 90% pure, or at least 95% pure, or at least 98% pure.
19. The polymorph form of rifaximin of claim 13 , wherein the polymorph form is at least 50% pure, or at least 75% pure, or at least 80% pure, or at least 90% pure, or at least 95% pure, or at least 98% pure.
20. The polymorph form of rifaximin of claim 15 , wherein the polymorph form is at least 50% pure, or at least 75% pure, or at least 80% pure, or at least 90% pure, or at least 95% pure, or at least 98% pure.
21. A method of treating a bowel related disorder comprising administering to a subject in need thereof an effective amount of the polymorph Form ζ of claim 9 , the polymorph Form η of claim 11 , the polymorph Form ζ of claim 13 , or the polymorph Form η of claim 15 .
22. The method of claim 21 , wherein the subject is suffering from at least one bowel related disorder selected from the group consisting of irritable bowel syndrome, travelers' diarrhea, small intestinal bacterial overgrowth, Crohn's disease, chronic pancreatitis, pancreatic insufficiency, enteritis and colitis.