Method and device for the intermittent occlusion of the coronary sinus

1. A system for the intermittently occluding a coronary sinus in a heart, comprising:

a multi-lumen catheter having an occlusion device along a distal end configured to be inserted into a coronary sinus of a heart via an atrium, wherein the occlusion device along the distal end of the multi-lumen catheter is intermittently adjustable to substantially occlude the coronary sinus of the heart;

a pressure measuring device connected to the multi-lumen catheter, the pressure measuring device being configured to measure a fluid pressure in the occluded coronary sinus when the occlusion device occludes of the coronary sinus, and the pressure measuring device being in communication with a memory that stores data indicative of a fluid pressure curve as a function of time based upon the measured fluid pressure in the occluded coronary sinus when the occlusion device occludes the coronary sinus; and

control circuitry configured to cause a release of the occlusion of the coronary sinus, wherein the control circuitry is configured to determine a pressure increase and/or pressure decrease per time unit while the coronary sinus is occluded by the occlusion device and configured to cooperate with the occlusion device to release the occlusion of the coronary sinus based at least in part on the pressure increase and/or pressure decrease per time unit.

2. The system of claim 1 , wherein the control circuitry is configured to determine the pressure increase per time unit occurring at consecutive heart beats and to cooperate with the occlusion device to release the occlusion of the coronary sinus based at least in part on the pressure increase per time unit occurring at consecutive heart beats.

3. The system of claim 1 , wherein the control circuitry is configured to determine a first derivative of the fluid pressure curve based upon the data stored in the memory that is indicative of the fluid pressure curve as the function of time.

4. The system of claim 3 , wherein the control circuitry is configured to determine the first derivative of the fluid pressure curve with respect to time as well as a local maximum of the first derivative occurring within a heart beat, and the control circuitry being configured to cooperate with the occlusion device in a manner that the occlusion of the coronary sinus is released after the local maxima of consecutive heart beats have reached a maximum.

5. The system of claim 1 , wherein the control circuitry is configured to trigger a start of a new occlusion of the coronary sinus using the occlusion device along the distal end of the multi-lumen catheter, wherein the control circuitry is configured to determine the pressure decrease per time unit and to cooperate with the occlusion device in a manner that the occlusion of the coronary sinus is triggered after the pressure decrease per time unit has reached a threshold.

6. The system of claim 5 , wherein the control circuitry is configured to determine a first derivative of the fluid pressure curve with respect to time as well as a local minimum of the first derivative occurring within a heart beat, and the control circuitry being configured to cooperate with the occlusion device in a manner that the occlusion of the coronary sinus is triggered after the local minima of consecutive heart beats have reached a minimum.

7. The system of claim 1 , wherein the multi-lumen catheter comprises a balloon inflation lumen that is connectable to a pump.

8. The system of claim 7 , wherein the control circuitry is configured to deliver control signals to the pump so as to start and stop the pump when connected to the balloon inflation lumen.

9. The system of claim 1 , wherein the pressure measuring device measures systolic pressure peaks occurring at consecutive heart beats while the coronary sinus is occluded.

10. The system of claim 9 , wherein the pressure measuring device measures diastolic pressure valleys in the coronary sinus occurring between the systolic pressure peaks.