Poly(diol citrate) elastomers
View Patent ↗The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using a citric acid copolymers.
1. A thermoset elastomer comprising crosslinked polyesters having the formula:
wherein R is selected from a hydrogen or a poly(diol citrate); and
wherein each A is O(CH 2 ) x O, wherein x is 7-14.
2. The thermoset elastomer of claim 1 , wherein each A is O(CH 2 ) 8 O, O(CH 2 ) 10 O, or O(CH 2 ) 12 O.
3. The thermoset elastomer of claim 1 , produced by the polycondensation of citric acid with a linear alkane diol having the formula HO(CH 2 ) x OH, wherein x is 7-14.
4. The thermoset elastomer of claim 2 , produced by the polycondensation of citric acid with one or more of 1,8-ocantediol, 1,10-decanediol, and 1,12-dodecanediol.
5. The thermoset elastomer of claim 1 , wherein each A is the same.
6. The thermoset elastomer of claim 1 , wherein the polyester network is biodegradeable.
7. The thermoset elastomer of claim 1 , wherein the polyester network is biocompatable.
8. The thermoset elastomer of claim 1 , wherein said insoluble polyester network is porous.
9. The thermoset elastomer of claim 1 , wherein said insoluble polyester network is non-porous.