DICKKOPF-1 expression modulating compositions and uses thereof
View Patent ↗The present invention relates generally to compositions for topical application to the skin which comprise at least one DICKKOPF-1 expression modulator and the use of such compositions to provide benefits to the skin, including but not limited to lightening or darkening skin; treating hyper or hypopigmented skin; increasing or decreasing skin thickness; reducing or increasing skin hirsuteness; and/or changing skin phenotype from non-palmoplantar to palmoplantar.
1. A method for treating fine lines and/or wrinkles, comprising topically applying to an area of skin in need thereof an effective amount of a composition comprising an effective amount of a DICKKOPF-1 expression increasing agent in a cosmetically acceptable vehicle, wherein said DICKKOPF-1 expression increasing agent comprises an extract of the yeast Pichia pastoris which, before being extracted, has been fermented in the presence of a Clintonia borealis extract.
2. The method of claim 1 , with the proviso that the DICKKOPF-1 expression increasing agent excludes unmetabolized C. borealis extract.
3. The method according to claim 1 , wherein said DICKKOPF-1 expression increasing agent is present in the composition at between about 0.0001% by weight and about 10% by weight.
4. The method according to claim 1 , wherein the extract of the yeast exhibits a pH of between about 5.0 to about 7.0 when added to the composition.
5. The method according to claim 1 , wherein the C. borealis extract is an aqueous C. borealis extract.
6. The method according to claim 1 , wherein said composition further comprises at least one skin lightener, selected from thiodipropionic acid (TDPA) or an ester derivative thereof.
7. A method for improving skin thickness, plumpness, and/or tautness, comprising topically applying to an area of skin in need thereof an effective amount of a composition comprising an effective amount of a DICKKOPF-1 expression increasing agent in a cosmetically acceptable vehicle, wherein said DICKKOPF-1 expression increasing agent comprises an extract of the yeast Pichia pastoris which, before being extracted, has been fermented in the presence of a Clintonia borealis extract.
8. The method according to claim 1 , wherein said DICKKOPF-I expression increasing agent is applied to skin exhibiting a non-palmoplantar phenotype.
9. The method of claim 1 , wherein the extract of the yeast includes cytolasmic and extracellular components extracted from the yeast fermented in the presence of the C. borealis extract.
10. The method of claim 7 , wherein the extract of the yeast includes cytolasmic and extracellular components extracted from the yeast fermented in the presence of the C. borealis extract.