Administration regime for N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2- ylcarbonylamino]ethoxy}benzamide
View Patent ↗N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterized in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.
1. A method of treating cancer in a subject in need thereof; comprising administration of an effective amount of N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}benzamine of formula (I):
or an addition salt thereof with a pharmaceutically acceptable acid or base; alone or in combination with a surgery, chemotherapy, hormone therapy treatment or radiotherapy. wherein the compound of formula (I), or an addition salt thereof with a pharmaceutically acceptable acid or base. is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of the compound of formula (I), or an addition salt thereof with a pharmaceutically acceptable acid or base, with the proviso that the chemotherapy is not FOLFOX (oxaliplatin/folinic acid/5-fluorouracil).
2. The method according to claim 1 , wherein the compound of formula (I) is administered in the form of a hydrochloride.
3. The method according to claim 1 , wherein the compound of formula (I), or an addition salt thereof with a pharmaceutically acceptable acid or base, is administered for 4 consecutive days at a rate of 2 administrations per day, that period being followed by 3 consecutive days without any administration of the compound of formula (I).
4. The method according to claim 1 , wherein the compound of formula (I), or an addition salt thereof with a pharmaceutically acceptable acid or base, is administered in combination with a chemotherapy, hormone therapy treatment, or radiotherapy.
5. The method according to claim 1 , wherein the cancer is carcinoma, tumours, neoplasm lymphoma, melanoma, glioma, sarcoma, or blastoma.
6. The method according to claim 1 , wherein the cancer comprises solid tumours.
7. The method according to claim 1 , wherein the cancer is breast cancer.
8. The method according to claim 1 , wherein the cancer is ovarian carcinoma, fallopian tube carcinoma, or prima peritoneal carcinoma.
9. The method according claim 1 , wherein the chemotherapy treatment is cisplatin, doxorubicin or pegylated liposomal doxorubicin.
10. The method according to claim 1 , wherein the hormone therapy treatment is tamoxifen.