VASO-OCCLUSIVE DEVICE
A vaso-occlusive device includes a coil made from coil wire, wherein the coil wire includes a core containing a core material having a first electrical potential covered by a coating containing a coating material having a second electrical potential, wherein the second electrical potential is less than the first electrical potential. A method of manufacturing a vaso-occlusive device includes cladding a core with a magnesium containing coating to form a wire, wrapping the wire around a mandrel to form a coil, and heat-setting the coiled wire. A method of occluding a body cavity with a vaso-occlusive device includes delivering the vaso-occlusive device to a body cavity and inducing a reduction reaction in the body cavity and adjacent the vaso-occlusive device, wherein the reduction reaction reduces infections and promotes cell proliferation in the body cavity.
1 . A vaso-occlusive device, comprising a coil made from coil wire, wherein the coil wire includes a core containing a core material having a first electrical potential covered by a coating containing a coating material having a second electrical potential, wherein the second electrical potential is less than the first electrical potential.
2 . The vaso-occlusive device of claim 1 , wherein the second electrical potential is at least 20% less than the first electrical potential.
3 . The vaso-occlusive device of claim 1 , wherein the coating material is magnesium.
4 . The vaso-occlusive device of claim 3 , wherein the coating comprises pure magnesium.
5 . The vaso-occlusive device of claim 3 , wherein the coating comprises a magnesium alloy.
6 . The vaso-occlusive device of claim 3 , wherein the coating comprises porous magnesium.
7 . The vaso-occlusive device of claim 3 , wherein the coating comprises a magnesium-iron alloy.
8 . The vaso-occlusive device of claim 1 , wherein the coating is clad onto the core.
9 . The vaso-occlusive device of claim 1 , wherein the core material is selected from the group consisting of biologically compatible polymers, biologically compatible ceramics, and biologically compatible metals.
10 . The vaso-occlusive device of claim 9 , wherein the core material is a biologically compatible metal selected from the group consisting of platinum, platinum-tungsten alloy, platinum-iridium alloy, platinum-rhenium alloy, and platinum-palladium alloy.
11 . The vaso-occlusive device of claim 9 , wherein the core material is a biologically compatible polymer or a biologically compatible ceramic, the core further comprising a radiopaque agent.
12 . The vaso-occlusive device of claim 11 , wherein the radiopaque agent is selected from the group consisting of barium particles, barium fibers, iodine particles, iodine particles, tungsten particles, tungsten fibers, platinum particles, and platinum fibers.
13 . The vaso-occlusive device of claim 9 , wherein the core material is a biologically compatible polymer or a biologically compatible ceramic, the coating further comprising a radiopaque agent.
14 . The vaso-occlusive device of claim 13 , wherein the radiopaque agent is selected from the group consisting of barium, iodine, tungsten, and platinum.
15 . The vaso-occlusive device of claim 1 , wherein the coating comprises nano pores.
16 . The vaso-occlusive device of claim 15 , further comprising a lubricious liquid disposed in the nano pores.
17 . A method of manufacturing a vaso-occlusive device according to claim 3 , comprising:
cladding a core containing a core material having a first electrical potential with a coating containing a coating material having a second electrical potential to form a wire, wherein the second electrical potential is less than the first electrical potential;
wrapping the wire around a mandrel to form a coil; and
heat-setting the coiled wire.
18 . The method of claim 17 , wherein the coating material is magnesium.
19 . A method of occluding a body cavity with a vaso-occlusive device according to claim 1 , comprising:
delivering the vaso-occlusive device to a body cavity; and
inducing a reduction reaction in the body cavity and adjacent the vaso-occlusive device, wherein the reduction reaction reduces infections and promotes cell proliferation in the body cavity.
20 . The method of claim 19 , further comprising:
delivering a second vaso-occlusive device to the body cavity; and
inducing a second reduction reaction in the body cavity and adjacent the second vaso-occlusive device,
wherein the second vaso-occlusive device does not contain the coating material, and wherein the second reduction reaction reduces infections and promotes cell proliferation in the body cavity.