IP Library › Granted Patent US 9,561,197
Granted Patent B2
US 9,561,197 · App. 13/610,580 · Granted Feb 7, 2017

Methods of therapeutic monitoring of phenylacetic acid prodrugs

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Quick Facts
Patent No.
US 9,561,197
App. No.
13/610,580
Granted
Feb 7, 2017
Kind
B2
Abstract

The present disclosure provides methods for adjusting the dosage of PAA prodrugs (e.g., HPN-100, PBA) based on measurement of PAA and PAGN in plasma and calculating the PAA:PAGN ratio so as to determine whether PAA to PAGN conversion is saturated.

Claims (2)

1. A method of treating a urea cycle disorder in a subject comprising administering to a subject having a plasma PAA to PAGN ratio outside the target range of 1 to 2, a dosage of glyceryl tri-[4-phenylbutyrate] (HPN-100) effective to achieve a plasma PAA to PAGN ratio within the target range of 1 to 2.

2. A method of treating a urea cycle disorder in a subject comprising administering to a subject having a plasma PAA to PAGN ratio outside the target range of 1 to 2.5, a dosage of glyceryl tri-[4-phenylbutyrate] (HPN-100) effective to achieve a plasma PAA to PAGN ratio within the target range of 1 to 2.5.

Assignments (10)
MERGER AND CHANGE OF NAME Recorded Dec 21, 2023
From: HORIZON THERAPEUTICS, LLC; HORIZON ORPHAN LLC
To: HORIZON THERAPEUTICS U.S. HOLDING LLC
Reel/Frame 065928/0608 →
RELEASE OF SECURITY INTEREST Recorded Oct 6, 2023
From: CITIBANK, N.A.
To: HORIZON THERAPEUTICS U.S. HOLDING LLC (SUCCESSOR IN INTEREST TO HORIZON THERAPEUTICS, INC.)
Reel/Frame 065153/0961 →
CORRECTIVE ASSIGNMENT TO CORRECT THE TWO PATENT NUMBERS PREVIOUSLY RECORDED AT REEL: 039640 FRAME: 0886. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded Apr 17, 2017
From: HORIZON THERAPEUTICS INC.
To: HORIZON THERAPEUTICS, LLC
Reel/Frame 043156/0175 →
CHANGE OF NAME Recorded Aug 26, 2016
From: HORIZON THERAPEUTICS, INC.
To: HORIZON THERAPEUTICS, LLC
Reel/Frame 039640/0886 →
CHANGE OF NAME Recorded Aug 9, 2016
From: HORIZON THERAPEUITCS, INC.
To: HORIZON THERAPEUTICS, LLC
Reel/Frame 039633/0851 →
PATENT SECURITY AGREEMENT Recorded Aug 6, 2015
From: HORIZON THERAPEUTICS, INC.
To: CITIBANK, N.A.
Reel/Frame 036314/0141 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ADDRESS OF RECEIVING PARTY PREVIOUSLY RECORDED AT REEL: 035638 FRAME: 0305. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded May 18, 2015
From: HYPERION THERAPEUTICS, INC.
To: HYPERION THERAPEUTICS, INC.
Reel/Frame 035716/0067 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S NAME PREVIOUSLY RECORDED AT REEL: 035638 FRAME: 0305. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded May 18, 2015
From: HYPERION THERAPEUTICS, INC.
To: HORIZON THERAPEUTICS, INC.
Reel/Frame 035716/0190 →
CHANGE OF NAME Recorded May 14, 2015
From: HYPERION THERAPEUTICS, INC.
To: HORIZON THERAPEUTICS, INC.
Reel/Frame 035638/0305 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 21, 2012
From: SCHARSCHMIDT, BRUCE; MOKHTARANI, MASOUD
To: HYPERION THERAPEUTICS, INC.
Reel/Frame 029337/0054 →