Compositions for modulating a kinase cascade and methods of use thereof
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.
1. A polymorph of a salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide characterized by an X-ray diffraction pattern substantially similar to that set forth in any one of FIGS. 20-28 .
2. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 20 , and wherein said salt is a p-tosylate.
3. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 21 , and wherein said salt is a p-tosylate.
4. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 22 , and wherein said salt is a fumarate.
5. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 23 , and wherein said salt is a maleate.
6. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 24 , and wherein said salt is a bis-maleate.
7. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 25 , and wherein said salt is a bis-fumarate.
8. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 26 , and wherein said salt is a bis-fumarate.
9. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 27 , and wherein said salt is a bis-phosphate.
10. The polymorph of claim 1 , characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 28 , and wherein said salt is a bis-p-tosylate.