Zero-heat-flux, deep tissue temperature measurement devices with thermal sensor calibration

1. A zero-heat-flux temperature device with first and second flexible substrate layers sandwiching a layer of thermally insulating material, comprising:

a heater trace disposed on the first substrate layer defining a heater surrounding a zone of the first substrate layer having no heater trace,

a first thermal sensor disposed in the zone of the first substrate layer having no heater trace,

a thermal sensor calibration device,

a second thermal sensor disposed on the second substrate layer,

a plurality of connection pads, and a plurality of conductive traces connecting the heater trace and the first and second thermal sensors with the plurality of connection pads.

2. The zero-heat-flux temperature device of claim 1 , in which the thermal sensor calibration device includes a programmable memory.

3. The zero-heat-flux temperature device of claim 1 , in which the flexible substrate includes a center section, a tab extending outwardly from the periphery of the center section, and a tail extending outwardly from the periphery of the center section, the plurality of connection pads is disposed on the tab, and the center section and the tail are folded around the layer of thermal insulating material such that the center section constitutes the first substrate layer and the tail constitutes the second substrate layer.

4. The zero-heat-flux temperature device of claim 3 , in, which the thermal sensor calibration device is disposed on a surface portion of the substrate extending partially over the tab and the center section.

5. The zero-heat-flux temperature device of claim 4 , in which the thermal sensor calibration device includes a programmable memory.

6. The zero-heat-flux temperature device of claim 3 , in which the thermal sensor calibration device is disposed between the heater and the plurality of connection pads.

7. The zero-heat-flux temperature device of claim 6 , in which the plurality of conductive traces includes conductive traces connecting the thermal sensor calibration device with connection pads of the plurality of connection pads.

8. The zero-heat-flux temperature device of claim 3 , in which the tab includes opposing notches.

9. The zero-heat-flux temperature device of claim 8 , in which the annular heater trace includes two terminal ends and a first connection pad of the plurality of connection pads is connected only to a first terminal end of the heater trace and a second connection pad of the plurality of connection pads is connected only to the second terminal end of the heater trace.

10. The zero-heat-flux temperature device of claim 8 , in which the annular heater trace includes three terminal ends and a first connection pad of the plurality of connection pads is connected only to a first terminal end of the heater trace, a second connection pad of the plurality of connection pads is connected only to the second terminal end of the heater trace, and a third connection pad of the plurality of connection pads is connected only to the third terminal end of the heater trace.

11. A temperature device, comprising:

a flexible substrate; and,

an electrical circuit on the flexible substrate, the electrical circuit including an annular heater trace surrounding a zone of the flexible substrate having no heater trace, a first thermistor disposed in the zone of the flexible substrate having no heater trace, a second thermistor disposed outside of the annular heater trace, a thermistor calibration device, a plurality of connection pads, and a plurality of conductive traces connecting the first and second thermistors, the thermistor calibration device, and the annular heater trace with the plurality of connection pads.

12. The temperature device of claim 11 , in which the plurality of connection pads includes six or seven connection pads.

13. The temperature device of claim 11 , in which the thermistor calibration device is a programmable memory device storing thermistor calibration coefficients.

14. The temperature device of claim 11 , in which the thermistor calibration device is disposed on a surface portion of the flexible substrate between the heater trace and the connection pads.

15. The temperature device of claim 14 , in which the thermistor calibration device is a programmable memory device storing thermistor calibration coefficients.

16. The temperature device of claim 15 , in which the plurality of connection pads includes six or seven connection pads.