Adenosine derivative formulations for medical imaging
View Patent ↗A stable composition useful for myocardial perfusion imaging contains one or more 2-alkynyladenosine derivatives; and a solvent which is made up of water and hydroxypropyl-β-cyclodextrin.
1. A stable composition useful for myocardial perfusion imaging, comprising:
(a) an adenosine derivative, which is methyl trans-4-[3-[6-amino-9-(N-ethyl-β-D-ribofuranosyluronamide)-9H-purin-2-yl]prop-2-ynyl]cyclohexane carboxylate or a pharmaceutically acceptable salt thereof; and,
(b) a solvent consisting essentially of water and hydroxypropyl-β-cyclodextrin.
2. The composition of claim 1 , further comprising a buffer.
3. The composition of claim 2 , wherein the buffer comprises: sodium citrate and citric acid.
4. The composition of claim 1 , wherein the concentration of hydroxypropyl-β-cyclodextrin is about 0.1-10% w/v.
5. The composition of claim 4 , wherein the concentration of hydroxypropyl-β-cyclodextrin is about 0.5-2% w/v.
6. The composition of claim 1 , wherein the molar ratio of the adenosine derivative to hydroxypropyl-β-cyclodextrin is about 1:30 to 1:150.
7. The composition of claim 1 , wherein hydroxyethyl-β-cyclodextrin is absent from the composition.
8. The composition of claim 1 , wherein any other β-cyclodextrin is absent from the composition.
9. The composition of claim 1 , wherein any other solvent is absent from the composition.
10. The composition of claim 1 , wherein the composition is storage stable for at least about 3 months.
11. A cardiovascular stress testing kit, comprising:
(a) an adenosine derivative, which is methyl trans-4-[3-[6-amino-9-(N-ethyl-β-D-ribofuranosyluronamide)-9H-purin-2-yl]prop-2-ynyl]cyclohexane carboxylate or a pharmaceutically acceptable salt thereof; and,
(b) a solvent consisting essentially of water and hydroxypropyl-β-cyclodextrin.
12. The kit of claim 11 , wherein hydroxyethyl-β-cyclodextrin is absent from the solvent.