Reinforced biologic material
View Patent ↗The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.
1. An implantable medical device, comprising:
a plurality of first elongate non-biologic elements, at least a portion of which are under a tensile or compressive stress prior to implantation;
at least one biologic component comprising a biomatrix surrounding at least a portion of the plurality of first elongate non-biologic elements; and
at least one second elongate non-biologic element, wherein the at least one second element secures at least one end portion of the plurality of first elongate non-biologic elements;
wherein the plurality of first elongate non-biologic elements have a higher load capacity than the at least one biologic component at the time of implantation; and
wherein the at least one biologic component has a higher load capacity than the plurality of first elongate non-biologic elements after implantation and following growth of native cells within the biomatrix.
2. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises at least one material chosen from bioabsorbable polymer, bioabsorbable metal, or a combination of bioabsorbable polymer and bioabsorbable metal.
3. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprise at least one material chosen from polyhydroxyalkanoate, poly-hydroxybutyrate, polylactic acid (PLA), polyglycolic acid (PGA), polylactideglycolide acid (PLGA), polydioxanone (PDO), polycaprolactone (PCL), a polyanhydride, a polyorthoester, a poly(amino acid), a polypeptide, a polydepsipeptide, a nylon-2/nylon-6 copolyamide, a poly(alkylene succinate), poly(hydroxyl butyrate) (PHB), poly(butylene diglocolate), poly(.epsilon.-caprolactone), a polydihydropyran, a polyphosphazene, a poly(cyano acrylates), modified polysaccharides, cellulose, starch, chitin, modified proteins, collagen, fibrin, and combinations and copolymers thereof.
4. The implantable medical device of claim 1 , wherein the biomatrix comprises an acellular tissue matrix or a particulate acellular tissue matrix.
5. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises a bioabsorbable polymer, a bioabsorbable metal or a combination of a bioabsorbable polymer and bioabsorbable metal.
6. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements are under a tensile stress ranging from greater than 0 N to about 1800 N.
7. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises a plurality of threads, cords, cables, ribbons, or braids.
8. The implantable medical device of claim 1 , wherein the at least one biologic component at least partially separates the elongate first elements comprised within the plurality of elongate first non-biologic elements.
9. The implantable medical device of claim 1 , wherein the at least one biologic component at least partially coats each element comprised within the plurality of first elongate non-biologic elements.
10. The implantable medical device of claim 1 , wherein the at least one biologic component is in the form of a coating, a paste, a powder, or a liquid.
11. The implantable medical device of claim 1 , wherein the at least one second elongate non-biologic element secures at least one end of the plurality of first elongate non-biologic elements by at least one of whipping, wrapping, and winding.
12. The implantable medical device of claim 1 , wherein the at least one second elongate non-biologic element comprises the same material as the plurality of first elongate non-biologic elements.
13. The implantable medical device of claim 1 , wherein at least a portion of the plurality of first elongate non-biologic elements are under a longitudinal tensile or compressive stress prior to implantation.
14. The implantable medical device of claim 1 , wherein at least a portion of the plurality of first elongate non-biologic elements are under a tensile or compressive stress of at least about 0.1 N prior to implantation.
15. The implantable medical device of claim 1 , wherein at least a portion of the plurality of first elongate non-biologic elements are under a tensile or compressive stress ranging from about 0.1 N to about 1800 N prior to implantation.
16. An implantable medical device, comprising:
a plurality of first elongate non-biologic elements, at least a portion of which are under a tensile or compressive stress prior to implantation;
at least one biologic component comprising a biomatrix surrounding at least a portion of the plurality of first elongate non-biologic elements; and
at least one second elongate non-biologic element, wherein the at least one second element secures at least one end portion of the plurality of first elongate non-biologic elements;
wherein the plurality of first elongate non-biologic elements have a higher load capacity than the at least one biologic component at the time of implantation;
wherein the at least one biologic component has a higher load capacity than the plurality of first elongate non-biologic elements after implantation and following growth of native cells within the biomatrix; and
wherein the at least one second elongate non-biologic element forms a screw-thread pattern compatible with threads of an anchoring screw.