Aryl-substituted pyrazoles
View Patent ↗The present invention relates to a process for preparing 1-aryl-substituted pyrazoles, comprising the reaction of alkoxy enones and enamino ketones with arylhydrazine derivatives to give 1-aryl-substituted dihydro-1H-pyrazoles, the further reaction thereof with elimination of water to give 1-aryl-substituted trihalomethylpyrazoles, and the further processing thereof.
1. A compound of the general formula (IV),
in which
X is fluorine, chlorine, bromine, or iodine;
R 3 is halogen, CN, NO 2 , alkyl, cycloalkyl, haloalkyl, halocycloalkyl, alkoxy, haloalkoxy, alkylamino, dialkylamino, or cycloalkylamino;
Z is CH, or N; and
R 4 is (C═O)(C 1 -C 6 )-alkyl, or (C═O)halo(C 1 -C 6 )-alkyl.
2. A compound of the general formula (V),
in which
X is fluorine, chlorine, bromine, or iodine;
R 3 is halogen, CN, NO 2 , alkyl, cycloalkyl, haloalkyl, halocycloalkyl, alkoxy, haloalkoxy, alkylamino, dialkylamino, or cycloalkylamino;
Z is CH, or N; and
R 4 is (C═O)(C 1 -C 6 )-alkyl, or (C═O)halo(C 1 -C 6 )-alkyl.
3. A compound of the general formula (IV) according to claim 1 , wherein
R 4 is (C═O)CH 3 and X is chlorine.
4. A compound of the general formula (V) according to claim 2 , wherein
R 4 is (C═O)CH 3 and X is chlorine.