Particulate materials
View Patent ↗The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process.
1. A method of administering an active substance by inhalation comprising:
providing the active substance in particulate form, the particulates comprising:
a volume mean aerodynamic diameter of less than 7 microns;
a bulk powder density within a range from about 0.1 g/cm 3 to about 0.5 g/cm 3 ; and
a surface-to-volume ratio of at least 2.5 times that of spherical particles of a corresponding volume diameter, wherein the particulates are solid, non-hollow, non-porous particles; and
administering the active substance to the respiratory tract.
2. The method of claim 1 , wherein the active substance further comprises a specific surface area of at least 10 m 2 /g.
3. The method of claim 1 , wherein the active substance further comprises a specific surface area of at least 20 m 2 /g.
4. The method of claim 1 , wherein the active substance further comprises a specific surface area of at least 25 m 2 /g.
5. The method of claim 1 , wherein the active substance further comprises a shape factor of at least 2.
6. The method of claim 1 , wherein the active substance further comprises a shape coefficient of greater than 10.
7. The method of claim 1 , wherein the active substance further comprises an aerodynamic shape factor of at least 1.4.
8. The method of claim 1 , wherein the active substance further comprises a volume mean diameter of less than 6 microns.
9. The method of claim 1 , wherein the active substance further comprises a specific surface energy of less than 100 mJ/m 2 .
10. The method of claim 1 , wherein the active substance further comprises a particle size distribution (X 90 ) within a range from about 0.5 μm to about 10 μm.
11. The method of claim 1 , wherein the active substance further comprises an amorphous phase content of less than 1% w/w.
12. The method of claim 1 , wherein the active substance further comprises a bulk powder density of about 0.2 g/cm 3 or less.
13. The method of claim 1 , wherein the active substance further comprises a shape factor of at least 3.5.
14. The method of claim 1 , wherein the active substance is selected from the group consisting of amphotericin-B, parathyroid hormone, glucagon-like peptide, an alkaloid ergotamine, and an anti-infective agent.
15. The method of claim 1 , wherein the active substance is selected from the group consisting of salbutamol, terbutalene, salmeterol, fenoterol, and bromocriptine or a pharmaceutically acceptable salt or mixture thereof.
16. The method of claim 1 , wherein the active substance is selected from the group consisting of insulin, pro-insulin, mono-acylated insulin, insulinotropin, and insulin-like growth factor.
17. The method of claim 1 , wherein the active substance is administered using a dry powder inhaler, the active substance having a fine particle fraction.
18. The method of claim 17 , wherein the fine particle fraction is about 20% or greater.
19. The method of claim 17 , wherein the fine particle fraction is about 31% or greater.
20. The method of claim 17 , wherein the fine particle fraction is about 55% or greater.