System and method for magnetic current density imaging at ultra low magnetic fields
View Patent ↗Preferred systems can include an electrical impedance tomography apparatus electrically connectable to an object; an ultra low field magnetic resonance imaging apparatus including a plurality of field directions and disposable about the object; a controller connected to the ultra low field magnetic resonance imaging apparatus and configured to implement a sequencing of one or more ultra low magnetic fields substantially along one or more of the plurality of field directions; and a display connected to the controller, and wherein the controller is further configured to reconstruct a displayable image of an electrical current density in the object. Preferred methods, apparatuses, and computer program products are also disclosed.
1. An imaging system comprising:
an electrical impedance tomography apparatus comprising one or more electrical leads adapted to deliver an electrical current through an object in a predetermined current direction;
an ultra low field magnetic resonance imaging apparatus comprising a plurality of field directions and disposable about the object and configured to emit one or more ultra low magnetic field pulses comprising one or more measurement magnetic fields ranging between one and three hundred microtesla in amplitude wherein an induced magnetic field generated b the electrical current is substantially parallel to at least one of the plurality of field directions;
a controller connected to the ultra low field magnetic resonance imaging apparatus and configured to implement a sequencing of the one or more ultra low magnetic field pulses substantially along one or more of the plurality of field directions, wherein the sequencing of the one or more ultra low magnetic field pulses comprises a first setting in which the ultra low magnetic field pulse is substantially parallel to the induced magnetic field and a second setting in which the ultra low magnetic field pulse is substantially perpendicular to the induced magnetic field; and
a display connected to the controller, and wherein the controller is further configured to reconstruct a displayable image of an electrical current density in the object.
2. The system of claim 1 , wherein the ultra low field magnetic resonance imaging apparatus comprises a detector array comprising one or more superconducting quantum interference devices arranged in a predetermined geometry.
3. The system of claim 1 , wherein the one or more measurement magnetic fields are less than one hundred microtesla in amplitude.
4. The system of claim 1 , wherein the object comprises a head and further comprising an electroencephalography apparatus configured to record electrical activity along at least a portion of the head.
5. The system of claim 1 , wherein the object comprises a head and further comprising a magneto-encephalography apparatus configured to record magnetic field activity within at least a portion of the head.
6. The system of claim 1 , wherein the object comprises a head and further comprising a transcranial brain stimulating apparatus configured to transmit an electrical pulse to at least a portion of the head.
7. A method comprising:
delivering an electrical current through an object in a predetermined current direction;
pulsing an ultra low magnetic field substantially parallel to the induced magnetic field wherein the ultra low magnetic field com rises a measurement magnetic field ranging between one and three hundred microtesla in amplitude;
changing the direction of the ultra low magnetic field by pulsing the ultra low magnetic field substantially perpendicular to the induced magnetic field wherein an induced magnetic field generated by the electrical current is substantially parallel to at least one of one or more field directions;
detecting a resonance between the electrical current and the ultra low magnetic field in the object; and
reconstructing an image of an electrical current density in the object in response to the detected resonance.
8. The method of claim 7 , wherein the measurement magnetic field is less than one hundred microtesla in amplitude.
9. The method of claim 7 , wherein the object comprises a head and further comprising performing an electroencephalogram on the head.
10. The method of claim 7 , wherein the object comprises a head and further comprising performing a magnetoencephalogram on the head.
11. The method of claim 7 , wherein the object comprises a head and further comprising performing transcranial brain stimulation in the head.
12. A computer program product comprising a non-transitory computer readable medium comprising computer executable code embodied therein, the computer executable code comprising a set of instructions to cause a computer to:
deliver an electrical current through an object in a predetermined current direction;
pulse an ultra low magnetic field substantially parallel to the induced magnetic field, wherein the ultra low magnetic field com rises a measurement magnetic field ranging between one and three hundred microtesla in amplitude;
change the direction of the ultra low magnetic field by pulsing the ultra low magnetic field substantially perpendicular to the induced magnetic, field wherein an induced magnetic field generated by the electrical current is substantially parallel to at least one of one or more field directions;
detect a resonance between the electrical current and the ultra low magnetic field in the object; and
reconstruct an image of an electrical current density in the object in response to the detected resonance.
13. The computer program product of claim 12 , wherein the measurement magnetic field is less than one hundred microtesla in amplitude.