Contact lenses having sensors with adjustable sensitivity
View Patent ↗Apparatus and methods employing contact lenses having electrochemical sensors that have adjustable analyte-sensing sensitivity are provided. In some aspects, level of the analyte or biological substance is detected and a number of sub-electrodes of the sensor are turned on or off based on the level of the analyte or biological substance. The sensitivity of the sensor is adjusted based on the number of sub-electrodes that are turned on or off. In some aspects, the current level from the sensor is employed in determining the number of sub-electrodes to turn on or off. In one aspect, a contact lens includes: a substrate; a power component; a circuit and an adjustment circuit. The circuit can include a potentiostat; and a sensor electrically coupled to the potentiostat, and configured to sense a level of an analyte. The sensitivity of the sensor can be adjustable by the adjustment circuit.
1. A contact lens, comprising:
a substrate;
a power component, disposed on or within the substrate, configured to output power;
a potentiostat, disposed on or within the substrate, and configured to be powered by the power component;
a sensor, disposed on or within the substrate, electrically coupled to the potentiostat, and configured to sense a level of an analyte in an eye over which the contact lens is configured to be worn, wherein the sensor comprises a working electrode having a plurality of sub-electrodes, and wherein a sensitivity of the sensor is adjustable; and
an adjustment circuit, disposed on or within the substrate, electrically coupled to the sensor, and configured to control the sensitivity of the sensor by turning one or more of the plurality of sub-electrodes on or off to the potentiostat.
2. The contact lens of claim 1 , wherein the adjustment circuit is further configured to control the sensitivity of the sensor by initiation of calibration of the sensor prior to operation of the contact lens.
3. The contact lens of claim 1 , wherein the adjustment circuit is further configured to dynamically control the sensitivity of the sensor based, at least, on feedback associated with a level of current output from the sensor.
4. The contact lens of claim 1 , wherein the adjustment circuit is further configured to dynamically control the sensitivity of the sensor based, at least, on feedback associated with the level of the analyte being sensed by the sensor.
5. The contact lens of claim 1 , wherein the contact lens further comprises a measurement circuit configured to measure a current signal from one or more of the plurality of sub-electrodes switched on to the potentiostat.
6. A contact lens, comprising:
an adjustment circuit configured to adjust a level of sensitivity of a sensor of the contact lens; and
a measurement circuit configured to:
determine a current output from the sensor, wherein the sensor comprises a plurality of sub-electrodes of a working electrode;
determine whether the current meets a predefined condition for adjustment of a number of the plurality of sub-electrodes, wherein adjustment comprises activation or de-activation of at least one of the plurality of sub-electrodes; and
output a feedback signal to the adjustment circuit in response to the predefined condition being met, wherein the feedback signal includes at least one of information indicative of a level associated with the current output from the sensor or information indicative of an adjustment to be performed by the adjustment circuit.
7. The contact lens of claim 6 , wherein the information indicative of the adjustment to be performed by the adjustment circuit comprises a number of the plurality of sub-electrodes to activate or de-activate.
8. The contact lens of claim 6 , wherein the predefined condition comprises the current being within a predefined range of values less than a maximum output current for which the measurement circuit is configured to perform measurement or the current being within a predefined range of values greater than a minimum output current for which the measurement circuit is configured to perform measurement.
9. The contact lens of claim 6 , further comprising:
adjusting a number of activated sub-electrodes prior to at least one of: receipt, by the measurement circuit, of a maximum output current for which the measurement circuit is configured to perform measurement or receipt, by the measurement circuit, of a minimum output current for which the measurement circuit is configured to perform measurement.
10. The contact lens of claim 6 , further comprising:
transmitting to a reader external to the contact lens, the current output from the sensor; and
receiving, from the reader, at least one of: information indicative of whether the predefined condition has been met or the information indicative of the adjustment to be performed by the adjustment circuit.
11. The contact lens of claim 6 , further comprising the sensor.
12. The contact lens of claim 6 , wherein the adjustment circuit comprises a plurality of switches coupleable to the plurality of sub-electrodes and configured to activate or de-activate one or more of the plurality of sub-electrodes.
13. An electrode system, comprising:
a counter electrode of an electrochemical sensor of a contact lens; and
a working electrode of the electrochemical sensor of the contact lens, the working electrode comprising a plurality of sub-electrodes configured to be turned on or off, wherein the electrode system is further configured to increase sensing sensitivity with an increase in a number of the plurality of sub-electrodes turned on and decrease sensing sensitivity with a decrease in a number of the plurality of sub-electrodes turned off.