Monoclonal antibodies and method of immunological analysis of D-dimer

1. An anti-D-dimer antibody, which specifically reacts with a D-dimer, wherein the D-Dimer is a plasmin digested product of stabilized fibrin, but does not react with (1), (2) and (3) as follows:

(1) Fibrinogen,

(2) fragment X, fragment Y, fragment D1 and fragment E3, which are plasmin-digested products of fibrinogen; and

(3) fragment DD, fragment E1 and fragment E2, which are dissociation products of a DD/E monomer, wherein said DD/E monomer is a basic unit of plasmin-digested products of stabilized fibrin.

2. A functional fragment of the antibody according to claim 1 .

3. A hybridoma which produces the antibody according to claim 1 .

4. A method of immunologically measuring the D-dimer contained in a biological sample, comprising the steps of:

labeling the antibody of claim 1 or a functional fragment thereof with a detectable moiety,

bringing the biological sample into contact with the labeled antibody or fragment to form an immunological complex, and

detecting the detectable moiety from the immunological complex, and

correlating it to a concentration; or

immobilizing the antibody of claim 1 or a functional fragment thereof on a solid phase,

bringing the biological sample into contact with the solid phase carrying the antibody or fragment,

detecting the degree of agglutination, and

correlating it to a concentration.

5. A reagent for immunologically measuring the D-dimer, comprising the antibody according to claim 1 or a functional fragment thereof.