EXAMINATION METHOD TO DETERMINE CONTRACTION OR ACTIVITY OF DISEASES RELATED IMMUNE SYSTEM OR JOINT SYSTEM

1 . A method for detecting diseases related to immune system and/or joint system,

wherein at least an miRNA selected from the group consisting of SEQ ID NOS: 1 to 5 contained in a blood-derived or joint-derived fluid sample is used as an index.

2 . An examination method for determining the activity of diseases related to immune system and/or joint system, comprising:

preparing blood-derived or joint-derived fluid samples collected over time,

measuring the expression levels of at least an miRNA selected from SEQ ID NOS: 1 to 5 in the fluid samples, and

comparing the expression levels between different sampling times.

3 . An examination method for determining the activity of diseases related to immune system and/or joint system, comprising:

preparing blood-derived fluid samples and joint-derived fluid samples collected over time,

measuring the expression levels of at least an miRNA selected from SEQ ID NOS: 1 to 5 in the fluid samples, and

comparing ratios (Ea/Eb) of the expression level (Ea) of miRNA obtained from the joint-derived fluid samples to the expression level (Eb) of miRNA obtained from the blood-derived fluid samples between different sampling times.

4 . An examination method for determining the contraction of diseases related to immune system and/or joint system, comprising:

measuring the expression level of miRNA of SEQ ID NO: 2 in a blood-derived fluid sample.

5 . An examination method for differentiating diseases related to immune system and/or joint system, comprising:

measuring the expression level of at least an miRNA selected from the group consisting of SEQ ID NOS: 1, 3, 4, and 5 in a joint-derived fluid sample.

6 . The method according to claim 1 , wherein the blood-derived fluid sample is plasma, and the joint-derived fluid sample is synovial fluid.

7 . Use of a primer or a probe capable of analyzing the expression level of miRNA selected from the group consisting of SEQ ID NOS: 1 to 5 in the manufacture of a kit for detecting diseases related to immune system and/or joint system.

8 . The method according to claim 2 , wherein the blood-derived fluid sample is plasma, and the joint-derived fluid sample is synovial fluid.

9 . The method according to claim 3 , wherein the blood-derived fluid sample is plasma, and the joint-derived fluid sample is synovial fluid.

10 . The method according to claim 4 , wherein the blood-derived fluid sample is plasma, and the joint-derived fluid sample is synovial fluid.

11 . The method according to claim 5 , wherein the blood-derived fluid sample is plasma, and the joint-derived fluid sample is synovial fluid.