N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
View Patent ↗The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R 1 , R 2 , R 3 and R 4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.
1. 1′-(1H-indazole-5-carbonyl)-1-isopropyl-4,6-dihydrospiro[indazole-5,4′-piperidin]7(1H)-one or a pharmaceutically acceptable salt thereof.
2. 1-(tert-butyl)-1′-(1H-indazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4′-piperidin]-7(1H)-one or a pharmaceutically acceptable salt thereof.
3. A compound that is
or a pharmaceutically acceptable salt thereof.
4. 1-isopropyl-1′-(1H-pyrrolo[3,2-b]pyridine-2-carbonyl)-4,6-dihydrospiro[indazole-5,4′-piperidin]-7(1H)-one or a pharmaceutically acceptable salt thereof.
5. A compound of structure
6. A compound of structure
7. A compound of structure
8. A compound of structure