GPR120 receptor agonists and uses thereof
GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
1. A compound of Formula (B-3) or (B-4):
wherein,
the ring Q is selected from the group consisting of aryl and
T 1 , T 2 , and T 3 are independently selected from the group consisting of CH and CH 2 , with the proviso that if one of T 1 , T 2 , and T 3 is CH, then —CR 4 R 5 — is attached to that T 1 , T 2 , or T 3 ;
X is selected from the group consisting of —CH 2 —, —CHD- and —CD 2 -;
Z is selected from the group consisting of H, alkyl, and substituted alkyl;
each R 3 is independently selected from the group consisting of halo, alkyl, substituted alkyl, alkoxy, and substituted alkoxy;
each R 4 and R 5 is independently selected from the group consisting of H and deuterium;
each R 6 is independently selected from the group consisting of halo, alkyl, substituted alkyl, and —OR a , wherein R a is alkyl;
the subscript k is 0, 1, 2 or 3; and
the subscript q is 0, 1, or 2;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein the compound is represented by Formula (C-3):
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 2 wherein R 3 is independently selected from the group consisting of F, Cl, —CH 3 , —CF 3 and —OCH 3 .
4. The compound of claim 3 , wherein each R 6 is independently selected from the group consisting of F, Cl, —CH 3 , —C 2 H 5 and —CF 3 .
5. The compound of claim 4 , wherein Z is H or alkyl.
6. The compound of claim 5 , wherein Z is H.
7. The compound of claim 6 , wherein q is 2.
8. The compound of claim 7 , wherein each of R 4 and R 5 is H.
9. The compound of claim 1 , wherein Q is