Compositions and methods for surface abrasion with frozen particles
View Patent ↗Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1. A method for abrasion of at least one biological tissue surface of a subject, comprising:
delivering in a single treatment to at least one biological tissue, at least two pluralities of frozen particle compositions in a predetermined sequential order, the first plurality of frozen particle compositions;
including one or more frozen particles approximately one micrometer or less;
and
wherein the first plurality includes two or more subsets having different therapeutic agents including at least one of ibuprofen, morphine, codeine, aspirin, acetaminophen, lidocaine/lignocaine, ropivacaine, mepivacaine, benzocaine, chloroprocaine, cocaine, cyclomethycaine, dimethocaine/larocaine, propoxycaine, procaine/novocaine, proparacaine, tetracaine/amethocaine, articaine, bupivacaine, carticaine, cincho caine/dibucaine, etidocaine, levobupivacaine, piperocaine, prilocaine, trimecaine, saxitoxin, or tetrodotoxin; and
subsequently in the same treatment, delivering a second plurality of frozen particle compositions;
including one or more frozen particles approximately one micrometer or less;
and wherein the second plurality includes at least two subsets having different agents including one or more of, keratin, collagen, elastin, cytokine, coagulant, anti-coagulant, anti-inflammatory agent, anti-tumor agent, antimicrobial agent, epinephrine, adrenaline, or a neurotoxin.
2. The method of claim 1 , wherein the one or more frozen particles are in one or more phases including ice Ic.
3. The method of claim 1 , wherein delivering at least one composition to at least one biological tissue includes propelling the composition toward the at least one biological tissue.
4. The method of claim 1 , wherein the delivering at least one composition to at least one biological tissue includes propelling, ejecting, or accelerating multiple frozen particles toward the at least one biological tissue.
5. The method of claim 1 , further comprising extracting or collecting material from the at least one abraded surface of at least one biological tissue.
6. The method of claim 1 , wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo.
7. The method of claim 6 , wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation.
8. The method of claim 7 , wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.
9. The method of claim 6 , wherein the at least one biological tissue is ingested by at least one subject.
10. The method of claim 1 , wherein the at least one biological tissue includes at least one cell mass.
11. The method of claim 1 , further including delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.
12. The method of claim 11 , wherein the detection material includes at least one electronic identification device.
13. The method of claim 11 , wherein the detection material includes at least one radioactive element.
14. The method of claim 11 , wherein the detection material includes at least one colorimetric substance.
15. The method of claim 11 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.
16. The method of claim 1 , wherein the subject includes at least one invertebrate or vertebrate animal.
17. The method of claim 12 , wherein the electronic identification device includes a radio frequency identification device.
18. The method of claim 1 , wherein one or more frozen particles in at least one of the first plurality or the second plurality include one or more reinforcement agents of at least one of polyaramid, vinylester matrix, ceramic, fiberglass, broad carbide, aromatic polyamide, nylon, silk, rayon, acetate, modacrylic, olefin, acrylic, polyester, aromatic polyester, vinyon, saran, spandex, vinalon, aromatic nylon, vinylidene chloride, modal, polybenzimidazole, lyocell, orlon, zylon, high-performance polyethylene, polypyridobenzimidazole, vectran, acrylonitrile rubber, glass, or steel.
19. The method of claim 1 , wherein the at least one composition is delivered to the biological tissue by way of a handheld device.
20. The method of claim 19 , wherein the handheld device includes at least one of a wand, pen, hose, sprayer, or gun.
21. The method of claim 1 , wherein the at least one composition is delivered to the biological tissue by way of a device included in a wall, corral, or gate.
22. The method of claim 1 , wherein the at least one composition is delivered to the biological tissue by way of a device including a cavity into which a subject may be placed for administration.