Method for making medical devices having antimicrobial coatings thereon
View Patent ↗The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag + ions associated with the —COO − groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
1. A method for preparing a medical device with an antimicrobial metal-containing LbL coating thereon, comprising the steps of: (a) alternatively applying, in no particular order, at least one layer of a negatively charged polyionic material having —COOAg groups and at least one layer of a positively charged polyionic material onto the medical device to form the polyelectrolyte LbL coating (b) autoclaving the medical device of step (a) to reduce the silver ions contained in the polyelectrolyte LbL coating to form silver nano-particles wherein the medical device having the silver nano-particle-containing antimicrobial LbL coating exhibits at least 50% inhibition of viable microorganisms.
2. A method for preparing a medical device with an antimicrobial metal-containing LbL coating thereon, comprising the steps of:
(a) obtaining a mold for making the medical device, wherein the mold comprises a first mold portion defining a first optical surface and a second mold portion defining a second optical surface, wherein said first mold portion and said second mold portion are configured to receive each other such that a medical device-forming cavity is formed between said first optical surface and said second optical surface;
(b) applying a transferable LbL coating, using a layer-by-layer polyelectrolyte deposition technique, onto at least one of said optical surfaces, wherein the transferable LbL coating comprises one or more bilayers of a negatively charged polyionic material having —COOAg groups and a positively charged polyionic material;
(c) positioning said first mold portion and said second mold portion such that said mold portions receive each other and said optical surfaces define said medical device forming cavity;
(d) dispensing a polymerizable composition into said medical device-forming cavity; and
(e) curing said polymerizable composition within said medical device-forming cavity such that the medical device is formed, whereby said transferable LbL coating detaches from said at least one optical surface of said mold portion and reattaches to said formed medical device such that said medical device becomes coated with the antimicrobial metal-containing LbL coating;
(f) autoclaving the medical device with the antimicrobial metal-containing LbL coating of step (e) to reduce the silver ions contained in the polyelectrolyte LbL coating to form silver nano-particles wherein the medical device having the silver nano-particle-containing antimicrobial LbL coating exhibits at least 50% inhibition of viable microorganisms.