METHOD FOR BONE STRUCTURE PROGNOSIS AND SIMULATED BONE REMODELING
Described herein are methods for analyzing bone structure and/or bone density, methods for estimating fracture risk in a subject as well as methods for monitoring the efficacy of an agent on bone structure and/or bone density.
1 . A method for analyzing bone structure or bone density,
the method comprising the steps of:
obtaining an image of a subject, wherein the image comprises an image of the subject's bone;
estimating probable volumetric structure of bone; and
measuring one or more parameters of estimated volumetric structure of bone.
2 . A method for monitoring the ability of an agent to affect bone quality, the method comprising the steps of
(a) obtaining bone quality measurements on a subject, wherein the bone quality measurements are obtained using the method according to claim 1 ;
(b) administering an agent to the subject;
(c) obtaining bone quality measurements of the subject after administration of the agent, wherein the bone quality measurements are obtained using the method according to claim 1 ;
(d) comparing bone quality measurements from steps (a) and (c), wherein a difference between in bone quality measurements between (a) and (c) is due to the effect of the agent.