Compensation of volumetric errors in a gas monitoring system
View Patent ↗A mainstream gas monitoring method includes a using a mainstream airway adapter and a gas sensing assembly associated with the mainstream airway adapter to measure an analyte of a gas flow through the adapter. A gas sensing portion outputs a signal indicative of the analyte in a gas flow in the mainstream airway adapter. A processing portion receives the signal from the gas sensing portion and determines an amount of the analyte in the gas flow based on the signal from the gas sensing portion. The processing portion also compensates for volumetric differences between the gas flow during inspiration and the gas flow during expiration to maximize the accuracy in the measurements.
1. A method of monitoring an analyte in a gas flow comprising the acts of:
providing mainstream airway adapter having the gas flow therethrough;
producing by a gas sensing portion a signal indicative of the analyte in the gas flow;
determining by a processing portion an amount of the analyte in the gas flow based on the signal from the gas sensing portion;
compensating by the processing portion for volumetric differences between the gas flow during inspiration and the gas flow during expiration; and
outputting a signal indicative of the amount of analyte in a human perceivable format,
wherein the compensating act includes monitoring a tracheal dead space gas and using the monitored tracheal dead space gas to determine a difference between an analyte fraction of inspired gas and an analyte fraction of the tracheal dead space gas for determining the amount of the analyte in the gas flow.
2. The method of claim 1 , wherein the first portion of gas exhaled during the expiration is a remaining gas of inspired gas, where the remaining gas has remained in a trachea and has been heated to body temperature and humidified by the trachea, and did not participate in gas exchange in lungs where oxygen has not been removed by lungs from the remaining gas.
3. The method of claim 1 , wherein the analyte is oxygen, and the method further comprising the act of determining oxygen consumption (VO 2 ) based on the amount of analyte.
4. The method of claim 1 , further comprising the act of determining a flow rate of the gas flow, and wherein determining the amount of the analyte includes the acts of:
determining oxygen concentration in the gas flow; and
determining carbon dioxide in the gas flow.
5. The method of claim 4 , further comprising the act of determining oxygen consumption VO 2 as:
VO 2 =V E *Fi O2 — Ds −*((1−Fe CO2 −Fe O2 )/(1−Fi CO2 −Fi O2 — DS ))−Fe O2 ],
where V E is an expired volume of gas, Fi O2 — DS is a tracheal dead space oxygen concentration, Fe CO2 is an expired carbon dioxide concentration, Fe O2 is an expired oxygen concentration, and Fi CO2 is an inspired carbon dioxide concentration.
6. The method of claim 1 , wherein the act of determining the amount of the analyte in the gas flow based on the signal from the gas sensing portion includes the acts of:
exciting a luminescable material with an excitation energy; and
monitoring quenching of a luminescence.
7. The method of claim 1 , further comprising the act of determining a flow rate of the gas flow, and wherein the act of determining the amount of the analyte includes determining an oxygen concentration in the gas flow.
8. The method of claim 7 , further comprising the act of determining oxygen consumption VO 2 as;
VO 2 =V i *Fi O2 — Ds −Ve*Fe O2 ,
where Vi is an inspired volume of gas, Fi O2 — DS is a tracheal dead space oxygen concentration, V E is an expired volume of gas, and Fe O2 is an expired oxygen concentration.