Methods of improving the pharmacokinetics of doxepin
View Patent ↗Methods of improving the pharmacokinetics of doxepin in a patient.
1. A method of treating insomnia, the method comprising
administering between about 0.5 mg and about 7 mg doxepin to a patient in need thereof, wherein the doxepin is administered before bedtime and at least three hours after consuming a meal, thereby providing a faster onset of action and reducing next day residual effects.
2. The method of claim 1 , wherein the doxepin is administered in an amount of about 3 milligrams.
3. The method of claim 1 wherein the doxepin is administered in an amount of about 6 milligrams.
4. The method of claim 1 wherein the doxepin is administered as a tablet, capsule or liquid.
5. The method of claim 1 , wherein the doxepin is administered as a unit dosage form.
6. The method of claim 1 , wherein the doxepin is administered as an oral dosage form.
7. The method of claim 1 , wherein the doxepin is administered within about one hour of bedtime.
8. A method for treating sleep maintenance insomnia, the method comprising:
administering between about 1 mg and about 6 mg doxepin to a patient in need thereof, wherein the doxepin is administered within about one hour before bedtime and at least three hours after consuming a meal, thereby providing a faster onset of action and reducing next day residual effects.
9. The method of claim 8 , wherein the doxepin is administered in an amount of about 3 mg.
10. The method of claim 8 , wherein the doxepin is administered in an amount of about 6 mg.
11. The method of claim 8 , wherein the doxepin is administered as a tablet, capsule or liquid.
12. The method of claim 8 , wherein the method shortens the median time to reach maximum plasma concentration (T max ) of doxepin in the patient compared to administering the doxepin with a high fat meal.
13. The method of claim 8 , wherein the method decreases the maximum plasma concentration (C max ) of doxepin in the patient compared to administering the doxepin with a high fat meal.
14. The method of claim 8 , wherein the method decreases the area under the curve (AUC) of doxepin in the patient compared to administering the doxepin with a high fat meal.