Granted Patent B2

US 8,927,527 · App. 13/655,618 · Granted Jan 6, 2015

Abstract

Claims (40)

1. A compound of structural Formula (I):

or a salt thereof, wherein:

R 1 , R 2 , R 3 and R 4 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, heteroarylalkyl, substituted heteroarylalkyl, halogen, hydroxy, or nitro;

R 5 and R 6 each represent independently for each occurrence hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, heteroarylalkyl, substituted heteroarylalkyl, halogen, hydroxy, or nitro;

R 7 is

a substituted acyl selected from the group consisting of substituted —C(O)-cycloalkyl, substituted —C(O)-aryl, substituted —C(O)-arylalkyl, substituted —C(O)-heteroaryl, substituted —C(O)-heteroarylalkyl, and an —C(O)-alkyl substituted by one or more substituents independently selected from the group consisting of halogen, —OR 60 , —SR 60 , —CF 3 , —OS(O) 2 R 60 , —OP(O)(OR 60 )(OR 61 ), and —OP(O)(OH) 2 ;

R 60 represents independently for each occurrence alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;

R 61 represents independently for each occurrence hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;

o is 0, 1, 2, 3 or 4; and

provided that at least two of R 1 , R 2 , R 3 , R 4 , —R 5 and R 6 are nitro.

2. The compound of claim 1 , wherein two of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are nitro.

3. The compound of claim 1 , wherein R 1 , R 2 , and R 3 are each independently hydrogen, alkyl, aryl, or nitro; and R 5 and R 6 each represent independently for each occurrence hydrogen, alkyl, aryl, or nitro.

4. The compound of claim 2 , wherein R 1 , R 2 , and R 3 are each independently hydrogen, alkyl, aryl, or nitro; and R 5 and R 6 each represent independently for each occurrence hydrogen, alkyl, aryl, or nitro.

5. The compound of claim 1 , wherein R 3 is nitro; and R 1 , R 2 , R 4 , R 5 , and R 6 each represent independently for each occurrence hydrogen, alkyl, aryl, or nitro.

6. The compound of claim 2 , wherein R 3 is nitro; and R 1 , R 2 , R 4 , R 5 , and R 6 each represent independently for each occurrence hydrogen, alkyl, aryl, or nitro.

7. The compound of claim 1 , wherein R 3 and R 4 are nitro; and R 1 , R 2 , R 5 , and R 6 each represent independently for each occurrence hydrogen, alkyl, or aryl.

8. The compound of claim 2 , wherein R 3 and R 4 are nitro; and R 1 , R 2 , R 5 , and R 6 each represent independently for each occurrence hydrogen or alkyl.

9. The compound of claim 1 , wherein R 7 is —C(O)-cycloalkyl, —C(O)-arylalkyl, —C(O)-heteroarylalkyl, or —C(O)-alkyl, each of which is substituted by one or more substituents independently selected from the group consisting of halogen, —OR 60 , and —OS(O) 2 R 60 .

10. The compound of claim 4 , wherein R 7 is —C(O)-cycloalkyl, —C(O)-arylalkyl, —C(O)-heteroarylalkyl, or —C(O)-alkyl, each of which is substituted by one or more substituents independently selected from the group consisting of halogen, —OR 60 , and —OS(O) 2 R 60 .

11. The compound of claim 1 , wherein R 7 is —C(O)-arylalkyl or —C(O)-alkyl, each of which is substituted by one or more substituents independently selected from the group consisting of halogen, —OR 60 , and —OS(O) 2 R 60 ; and R 60 is alkyl, substituted alkyl, aryl, or substituted aryl.

12. The compound of claim 4 , wherein R 7 is —C(O)-arylalkyl or —C(O)-alkyl, each of which is substituted by one or more substituents independently selected from the group consisting of halogen, —OR 60 , and —OS(O) 2 R 60 ; and R 60 is alkyl, substituted alkyl, aryl, or substituted aryl.

13. The compound of claim 1 , wherein R 7 is —C(O)-alkyl substituted with a halogen.

14. The compound of claim 4 , wherein R 7 is —C(O)-alkyl substituted with a halogen.

15. The compound of claim 1 , wherein R 7 is —C(O)—CH 3 substituted with a halogen.

16. The compound of claim 4 , wherein R 7 is —C(O)—CH 3 substituted with a halogen.

17. The compound of claim 8 , wherein R 7 is —C(O)—CH 3 substituted with a halogen.

18. The compound of claim 1 , wherein variable o is 2 or 3.

19. The compound of claim 4 , wherein variable o is 2 or 3.

20. The compound of claim 17 , wherein variable o is 2 or 3.

21. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable vehicle.

22. A compound of structural Formula (I):

or a salt thereof, wherein:

R 1 , R 2 , R 3 and R 4 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, heteroarylalkyl, substituted heteroarylalkyl, halogen, hydroxy, or nitro;

R 5 and R 6 each represent independently for each occurrence hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, heteroarylalkyl, substituted heteroarylalkyl, halogen, hydroxy, or nitro;

R 7 is —C(O)-alkyl substituted by one or more substituents independently selected from the group consisting of halogen, —OR 60 , —SR 60 , —CF 3 , —OS(O) 2 R 60 , —OP(O)(OR 60 )(OR 61 ), and —OP(O)(OH) 2 ;

R 60 represents independently for each occurrence alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;

R 61 represents independently for each occurrence hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;

o is 0, 1, 2, 3 or 4; and

provided that at least one of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are nitro.

23. A pharmaceutical composition comprising a compound of claim 22 and a pharmaceutically acceptable vehicle.

Assignments (12)