System and method for spray drying a liquid
View Patent ↗Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
1. A spray drying collection device, comprising:
an inlet port in fluid communication with the opposite end of a drying chamber;
a filter separating dried powder from humid air; and
an exhaust port allowing the humid air to exit the collection device.
2. The spray drying collection device of claim 1 , further comprising an outer wall, in which the inlet port and exhaust port are disposed along opposite sides.
3. The spray drying collection device of claim 2 , wherein the filter is disposed within the outer wall.
4. The spray drying collection device of claim 3 , further comprising a filter support attaching the filter to the outer wall.
5. The spray drying collection device of claim 1 , the filter forms a pouch-shaped collection chamber.
6. The spray drying collection device of claim 5 , wherein the pouch-shaped collection chamber is sized to accommodate dried powder resulting from processing of a single unit of liquid sample of a volume of no more than about 450 ml (about 0.951 pints).
7. The spray drying collection device of claim 1 , further comprising a rehydration fluid and means for selectively combining the rehydration fluid with the dried powder.
8. The spray drying collection device of claim 2 , wherein a volume defined by the outer wall is sized to accommodate a single unit of liquid sample of a volume of no more than about 450 ml (about 0.951 pints).
9. The spray drying collection device of claim 1 , wherein the filter comprises a filter media capable of creating a sterile barrier.