System and method for spray drying a liquid
View Patent ↗Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
1. A method for spray drying a liquid comprising:
aerosolizing a flow of liquid sample;
exposing the aerosolized flow of liquid sample to a heated drying gas adapted for separating the aerosolized flow of liquid sample into a dried powder and humid air; and
filtering the dried powder from the humid air.
2. The method of claim 1 , wherein the acts of aerosolizing the flow of liquid sample, exposing the aerosolized flow of liquid sample to a heated drying gas and filtering the dried powder from the humid air are accomplished along a common longitudinal axis.
3. The method of claim 1 , wherein the acts of aerosolizing the flow of liquid sample, exposing the aerosolized flow of liquid sample to a heated drying gas, and filtering the dried powder from the humid air, are accomplished within a processing assembly defining a sterilized volume, and at least substantial portions of the processing assembly having thin-walls and being flexible.
4. The method of claim 3 , wherein the flow of liquid sample is obtained from a single unit of liquid sample having a volume of no more than about 450 ml (about 0.951 pints).
5. The method of claim 4 , further comprising replacing the processing assembly prior to subsequently processing each single unit of liquid sample.
6. The method of claim 4 , wherein the act of filtering comprises separating the dried powder from the humid air and retaining the dried powder within an enclosed volume.
7. The method of claim 6 , further comprising sealing the dried powder within the enclosed volume thereby forming a sterile barrier to isolate the dried powder from external environmental conditions during storage.