Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
Disclosed herein are pharmaceutical compositions, methods and kits for lowering the serum uric acid level of a subject and for the treatment of a condition associated with elevated serum uric acid levels comprising administering a composition comprising a first urate-lowering agent and a second urate-lowering agent. In some aspects the first urate-lowering agent is (−)-halofenate, (−)-halofenic acid, or a pharmaceutically acceptable salts thereof. In some aspects the second urate-lowering agent is an inhibitor of uric acid production, a uricosuric agent, a uricase, or a pharmaceutically acceptable salt thereof.
1. A method of lowering the serum uric acid level of a subject with hyperuricemia, comprising concomitantly administering to the subject a therapeutically effective amount of a first urate-lowering agent that is (−)-halofenate, or a pharmaceutically acceptable salt thereof, substantially free from its (+)-enantiomer, and a second urate-lowering agent that is a xanthine oxidase inhibitor which is febuxostat, where the concomitant administration provides an additive or over-additive lowering of the serum uric acid level of the subject.
2. The method of claim 1 , where the first urate-lowering agent is (−)-halofenate.
3. The method of claim 1 where the first urate-lowering agent is administered at between about 100 mg/day and about 1000 mg/day.
4. The method of claim 1 , where the febuxostat is administered at between about 10 mg/day and about 240 mg/day.
5. The method of claim 2 , where the (−)-halofenate is administered at between about 400 mg/day and about 800 mg/day and the febuxostat is administered at between about 40 mg/day and about 120 mg/day.
6. The method of claim 5 , where the (−)-halofenate is administered at about 400 mg/day, about 500 mg/day, about 600 mg/day, about 700 mg/day, or about 800 mg/day.
7. A method of lowering the serum uric acid level of a subject with hyperuricemia, comprising concomitantly administering to the subject a therapeutically effective amount of a first urate-lowering agent that is (−)-halofenic acid or a pharmaceutically acceptable salt thereof, substantially free from its (+)-enantiomer, and a second urate-lowering agent that is a xanthine oxidase inhibitor which is febuxostat, where the concomitant administration provides an additive or over-additive lowering of the serum uric acid level of the subject.
8. The method of claim 7 , where the first urate-lowering agent is (−)-halofenic acid.
9. The method of claim 7 where the first urate-lowering agent is administered at between about 100 mg/day and about 1000 mg/day.
10. The method of claim 7 , where the febuxostat is administered at between about 10 mg/day and about 240 mg/day.
11. The method of claim 9 , where the (−)-halofenic acid is administered at about 100 mg/day, about 200 mg/day, about 300 mg/day, about 400 mg/day, about 500 mg/day, about 600 mg/day, about 700 mg/day, about 800 mg/day, about 900 mg/day, or about 1000 mg/day and the xanthine oxidase inhibitor is febuxostat and is administered at between about 40 mg/day and about 120 mg/day.