Manufacture, compositions and uses of coagulation factor VIIa modulator
View Patent ↗Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I:
1. A solution comprising:
a) a compound of Formula I or a salt thereof:
and
b) an amino acid buffer;
wherein the compound of Formula I or the salt thereof and the amino acid buffer are in solution.
2. The solution of claim 1 , further comprising an additional therapeutic agent, and a pharmaceutically acceptable excipient.
3. The solution of claim 1 , further comprising a divalent cation.
4. A solution comprising:
a) a compound of Formula I or a salt thereof:
b) an amino acid buffer;
c) an additional therapeutic agent;
d) a divalent cation; and
e) a pharmaceutically-acceptable excipient;
wherein the compound of Formula I or the salt thereof, the amino acid buffer, the additional therapeutic agent, the divalent cation and the pharmaceutically-acceptable excipient are dissolved in the solution.