Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
View Patent ↗The present invention relates to the use of nitric oxide releasing compounds for retarding or reversing muscular dystrophies such as Duchenne and Becker dystrophies.
1. A method of treating muscular dystrophies comprising administering to a subject a nitric oxide releasing compound of formula (Ia)
M-X—Y—ONO 2 (Ia)
or enantiomers or diastereoisomers thereof, wherein in the general formula (Ia), M, X and Y have the following meanings:
M is a residue
X is —O—, —S— or —NR 1 —, wherein R 1 is H or linear or branched C 1 -C 6 alkyl;
Y is a bivalent radical having the following meanings:
straight or branched C 1 -C 20 alkylene being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO 2 and T, wherein T is —OC(O)(C 1 -C 10 alkyl)-ONO 2 or —O(C 1 -C 10 alkyl)-ONO 2 ; or
—C 5 -C 7 cycloalkylene group optionally substituted with linear or branched C 1 -C 10 alkyl group.
2. The method of claim 1 , wherein X is —O— and Y is a straight C 4 alkylene chain.
3. The method of claim 1 , wherein the muscular dystrophy is Duchenne Muscular Dystrophy.
4. The method of claim 2 , wherein the muscular dystrophy is Duchenne Muscular Dystrophy.